Document Detail


Plasma levels of S100A4 in portopulmonary hypertension.
MedLine Citation:
PMID:  19399660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously showed that a single nucleotide polymorphism in S100A4 was associated with portopulmonary hypertension (PPHTN) in patients with advanced liver disease. We aimed to determine the association between plasma levels of S100A4 and PPHTN. We performed a case-control study of patients with advanced liver disease. Cases with PPHTN had mean pulmonary artery pressure >25 mmHg, pulmonary vascular resistance >240 dynes s cm(-5) and pulmonary capillary wedge pressure </=15 mmHg. Controls with liver disease had right ventricular systolic pressure <40 mmHg and normal right atrial and ventricular morphology by echocardiography. Plasma samples were assayed for S100A4. The study sample included 14 cases with PPHTN and 32 controls with liver disease. There was no difference in mean age between cases and controls (p = 0.52). Seventy-nine percent of cases were female compared with 44% of controls (p = 0.03). There was no difference in S100A4 levels between cases and controls (p = 0.58). Both groups had significantly higher S100A4 levels than healthy volunteers (p <0.05). There was no significant difference in plasma levels of S100A4 between PPHTN patients and controls with liver disease, although liver disease itself was associated with increased S100A4 levels.
Authors:
Tien Peng; Roham Zamanian; Michael J Krowka; Raymond L Benza; Kari E Roberts; Darren B Taichman; Debbie Rybak; James F Trotter; Robert S Brown; Michael B Fallon; Steven M Kawut;
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  14     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-28     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Affiliation:
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cohort Studies
Female
Humans
Hypertension, Pulmonary / blood*,  complications,  genetics
Liver Diseases / blood*,  complications,  genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
S100 Proteins / blood*,  genetics
Grant Support
ID/Acronym/Agency:
K23 HL067771-01/HL/NHLBI NIH HHS; K23 HL067771-02/HL/NHLBI NIH HHS; K23 HL067771-03/HL/NHLBI NIH HHS; K23 HL067771-04/HL/NHLBI NIH HHS; K23 HL067771-05/HL/NHLBI NIH HHS; K23 HL067771-06/HL/NHLBI NIH HHS; M01 RR000032/RR/NCRR NIH HHS; M01 RR000032-450782/RR/NCRR NIH HHS; M01 RR000032-450783/RR/NCRR NIH HHS; M01 RR000032-460782/RR/NCRR NIH HHS; M01 RR000032-460783/RR/NCRR NIH HHS; M01 RR000032-475112/RR/NCRR NIH HHS; M01 RR000032-475113/RR/NCRR NIH HHS; M01 RR000046-401009/RR/NCRR NIH HHS; M01 RR000046-40S11009/RR/NCRR NIH HHS; M01 RR000046-40S31009/RR/NCRR NIH HHS; M01 RR000046-40S41009/RR/NCRR NIH HHS; M01 RR000585-343140/RR/NCRR NIH HHS; M01 RR000645-331023/RR/NCRR NIH HHS; M01 RR000645-331039/RR/NCRR NIH HHS; M01 RR000645-341023/RR/NCRR NIH HHS; M01 RR000645-341039/RR/NCRR NIH HHS; R03 DK064103-01A1/DK/NIDDK NIH HHS; R03 DK064103-02/DK/NIDDK NIH HHS; R03 DK065958-01/DK/NIDDK NIH HHS; UL1 RR024156-01/RR/NCRR NIH HHS; UL1 RR024156-010001/RR/NCRR NIH HHS; UL1 RR024156-010002/RR/NCRR NIH HHS; UL1 RR024156-010003/RR/NCRR NIH HHS; UL1 RR024156-010004/RR/NCRR NIH HHS; UL1 RR024156-02/RR/NCRR NIH HHS; UL1 RR024156-027760/RR/NCRR NIH HHS; UL1 RR024156-027761/RR/NCRR NIH HHS; UL1 RR024156-027762/RR/NCRR NIH HHS; UL1 RR024156-027763/RR/NCRR NIH HHS; UL1 RR024156-02S1/RR/NCRR NIH HHS; UL1 RR024156-02S17772/RR/NCRR NIH HHS; UL1 RR024156-03/RR/NCRR NIH HHS; UL1 RR024156-035896/RR/NCRR NIH HHS; UL1 RR024156-035897/RR/NCRR NIH HHS; UL1 RR024156-035898/RR/NCRR NIH HHS; UL1 RR024156-035899/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/S100 Proteins; 142662-27-9/S100A4 protein, human
Investigator
Investigator/Affiliation:
Jefrey Okun / ; Daniel Rabinowitz / ; Evelyn M Horn / ; Lori Rosenthal / ; Sonja Olsen / ; Jenna Reinen / ; Vijay Shah / ; Russell Wiesner / ; Linda Stadheim / ; J Stevenson Bynon / ; Devin Eckhoff / ; Harpreet Singh / ; Rajasekhar Tanikella / ; Keith Wille / ; Dorothy Faulk / ; Lisa Forman / ; David Badesch / ; Ted Perry / ; Roshan Shrestha / ; Carrie Nielsen / ; Steven Zacks / ; Vivek Ahya / ; Harold Palevsky / ; Rajender Reddy / ; Michael Harhay / ; Sandra Kaplan / ; Neil Kaplowitz / ; James Knowles /
Comments/Corrections

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