| Plasma levels of NT-pro-BNP in patients with atrial fibrillation before and after electrical cardioversion. | |
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MedLine Citation:
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PMID: 16382379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Plasma levels of brain natriuretic peptide (BNP) have been examined in studies on patients with persistent atrial fibrillation, both before and after electrical cardioversion. Studied patients often showed a comorbidity with congestive heart failure, which complicates interpretation of measured BNP values as a natriuretic peptide. The aim of this study was to examine plasma levels of N-terminal fragment pro-brain natriuretic peptide (NT-pro-BNP), which is the more stable but inactive cleavage product of pro-BNP in patients with atrial fibrillation, but normal left ventricular ejection fraction, before and after electrical cardioversion. PATIENTS AND METHODS: NT-pro-BNP plasma levels of 34 consecutive patients were measured before, shortly after and 11 days after electrical cardioversion. All patients showed a normal ejection fraction after echocardiographic or laevocardiographic criteria. RESULTS: At baseline, all patients showed elevated NT-pro-BNP compared to a healthy control group (1086 vs. 66.9 pg/ml, p<0.001). After a mean follow-up time of 11 days in patients with persistent restored sinusrhythm, NT-pro-BNP decreased from 1071 pg/ml at baseline to 300 pg/ml (p<0.001). In contrast, patients with recurrence of atrial fibrillation showed increased levels from 1570.5 pg/ml at baseline to 1991 pg/ml (p=0.13; n.s.). Recurrence of atrial fibrillation was independent from height of NT-pro-BNP levels at baseline (p=0.23). CONCLUSIONS: Atrial fibrillation in patients with a normal left ventricular ejection fraction is associated with elevated NT-pro-BNP plasma levels, which decrease when a persistent sinus-rhythm can be restored by electrical cardioversion. On the other hand, NT-pro-BNP seems to increase (n.s.) when recurrence of atrial fibrillation occurs. Finally, NT-pro-BNP is no valid predictor for long-term success of sinus-rhythm restoration by electrical cardioversion. |
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Authors:
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D-I Shin; K Jaekel; Ph Schley; A Sause; M Müller; R Fueth; T Scheffold; H Guelker; M Horlitz |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Zeitschrift für Kardiologie Volume: 94 ISSN: 0300-5860 ISO Abbreviation: Z Kardiol Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-29 Completed Date: 2006-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0360430 Medline TA: Z Kardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 795-800 Citation Subset: IM |
Affiliation:
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HELIOS-Klinikum Wuppertal, Universitätsklinikum der Universität Witten-Herdecke, Herzzentrum Kardiologie, Medizinische Klinik III, Arrenberger Str. 20, 42117, Wuppertal, Germany. dshin@wuppertal.helios-kliniken.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atrial Fibrillation / blood*, diagnosis, therapy* Electric Countershock / methods* Female Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prognosis Reproducibility of Results Sensitivity and Specificity Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
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