Document Detail

Plasma levels of 6-keto-prostaglandin F1 alpha in normotensive subjects and patients with essential hypertension.
MedLine Citation:
PMID:  6348803     Owner:  NLM     Status:  MEDLINE    
To assess the pathophysiological role of prostacyclin in essential hypertension, plasma levels of 6-keto-prostaglandin F1 alpha (6-keto-PGF 1 alpha), a stable, nonenzymatic metabolite of prostacyclin, were assayed in 25 patients with essential hypertension and 25 age-matched normotensive subjects. Supine plasma levels of 6-keto-PGF1 alpha were 270 +/- 14 (SE) in normotensive subjects and 203 +/- 14 pg/ml in the patients with essential hypertension. The difference was statistically significant (p less than 0.001). There was a significant negative correlation between plasma levels of 6-keto-PGF1 alpha and systolic blood pressure (r = -0.44, P less than 0.002), diastolic blood pressure (r = -0.55, p less than 0.001), or mean blood pressure (r = -0.56, p less than 0.001) in the pooled subjects. The same relationship was found in the hypertensive patients. There was no definite relationship either between plasma levels of 6-keto-PGF1 alpha and plasma renin activity (PRA) in the supine position, or between changes in plasma levels of 6-keto-PGF1 alpha and changes in PRA after 60 min of upright posture. These results indicate that circulating prostacyclin is reduced in patients with essential hypertension as compared to normotensive subjects. This reduction of plasma prostacyclin may participate, in part, in the maintenance of blood pressure elevation in patients with essential hypertension. It is also suggested that upright posture is not sufficient to elevate circulating prostacyclin.
Y Uehara; M Ishii; T Ikeda; K Atarashi; T Takeda; S Murao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  11     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  95-104     Citation Subset:  IM    
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood*
Blood Pressure
Hypertension / blood*
Middle Aged
Renin / blood
Reg. No./Substance:
58962-34-8/6-Ketoprostaglandin F1 alpha; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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