Document Detail

Plasma leptin in infants: relations to birth weight and weight loss.
MedLine Citation:
PMID:  9481009     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The hormone leptin, produced in the adipose tissue, is involved in the regulation of body weight. The release of the hormone is increased in obese adults and decreased after fasting in human adults. This study investigated whether the plasma leptin level was related to the infant's birth weight and whether the level was reduced in connection with the physiological weight loss during the neonatal period. METHODS: We measured the plasma leptin level in cord blood from infants who were large for gestational age (LGA) (n = 15), small for gestational age (SGA) (n = 16), and appropriate for gestational age (AGA) (n = 38). AGA infants (n = 120), who were exclusively breastfed, were also studied during their first 4 postnatal days in a cross-sectional method. One blood sample was collected before breastfeeding from each infant. Plasma leptin concentrations were determined by radioimmunoassay. RESULTS: The median (range) concentration of leptin from cord blood was increased in LGA infants and decreased in SGA infants compared with the level in AGA infants. There was a positive correlation between the log of the plasma leptin level in cord blood and both the infant's birth weight (r = 0.76; n = 69) and the body mass index (r = 0.63; n = 69). The normal 3% to 6% weight reduction that occurs during the first 4 postnatal days was associated with a 26% decrease in the plasma leptin level in healthy breastfed infants. CONCLUSIONS: The plasma leptin level is highly correlated to the size of adipose tissue mass and decreases in connection with the initial physiological weight loss in newborn infants. These data provide evidence that leptin is highly related to the nutritional status already during the fetal and neonatal periods.
G Marchini; G Fried; E Ostlund; L Hagenäs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  101     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-03-10     Completed Date:  1998-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  AIM; IM    
Department of Woman and Child Health, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Adipose Tissue
Body Mass Index
Breast Feeding
Cross-Sectional Studies
Fetal Macrosomia / blood
Infant, Newborn / blood*
Infant, Small for Gestational Age / blood
Proteins / analysis,  metabolism*
Weight Loss / physiology*
Reg. No./Substance:
0/Leptin; 0/Proteins

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