Document Detail


Plasma kallikrein-kinin system in patients with uncomplicated sepsis and septic shock--comparison with cardiogenic shock.
MedLine Citation:
PMID:  3672421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alterations of the kallikrein-kinin system consistent with activation and increased consumption have been reported in septic patients and it has been suggested that this activation could contribute to the development of septic shock. The aim of this work was to confirm these alterations in septic patients and to investigate the possible existence of similar changes in subjects developing cardiogenic shock secondary to myocardial infarction as a model of non septic shock. Patients with septic shock, especially in fatal cases, showed a highly significant decrease in levels of factor XII, prekallikrein, high molecular weight kininogen (HMW-kininogen), alpha 2-macroglobulin (alpha 2-M) and antithrombin III (AT-III). C1-esterase inhibitor (C1-INH) activity was increased in uncomplicated sepsis but came back to normal or was slightly decreased in septic shock. Components and inhibitors of the kallikrein-kinin system were within normal limits in patients with cardiogenic shock. Our findings support the idea of a contribution of the kallikrein-kinin system to the development of septic shock though this system does not seem to play a significant role in the pathogenesis of cardiogenic shock or seem to be altered as a consequence of it.
Authors:
F Martínez-Brotóns; J R Oncins; J Mestres; V Amargós; C Reynaldo
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  58     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-12-14     Completed Date:  1987-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  709-13     Citation Subset:  IM    
Affiliation:
Department of Hematology, Hospital de Bellvitge, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Complement C1 Inactivator Proteins / blood
Factor XII / metabolism
Female
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans
Kallikreins / antagonists & inhibitors,  blood*
Kinins / antagonists & inhibitors,  blood*
Male
Middle Aged
Myocardial Infarction / complications
Sepsis / blood
Shock, Cardiogenic / blood*,  etiology
Shock, Septic / blood*,  etiology
Chemical
Reg. No./Substance:
0/Complement C1 Inactivator Proteins; 0/Kinins; 9001-30-3/Factor XII; EC 3.4.21.-/Kallikreins

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