| Plasma kallikrein clearance by the liver of normal and injured rats. | |
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MedLine Citation:
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PMID: 2610095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the clearance of rat plasma kallikrein (RPK) by the perfused livers of normal rats and from others at 2 and 4 days after subcutaneous injection of turpentine oil. RPK removal from the perfusate follows a logarithmic curve (y = a+b lnx) and from this equation its half-life of removal can be calculated. RPK clearance rate followed the potential equation y = axb. Both the half-life of RPK removal and RPK clearance rates were similar in the 3 groups of perfused livers. We conclude that, at the initial concentration of RPK used (approximately 3 nM), its liver clearance is not affected during the acute-phase response to inflammation. |
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Authors:
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C F Toledo; M Kouyoumdjian; D R Borges |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 247B ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-02-09 Completed Date: 1990-02-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 591-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Escola Paulista de Medicina, São Paulo, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Half-Life Inflammation / chemically induced, physiopathology* Kallikreins / blood, metabolism* Liver / enzymology* Rats Reference Values Turpentine |
| Chemical | |
Reg. No./Substance:
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8006-64-2/Turpentine; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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