Document Detail

Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase following intestinal ischemia in pigs.
MedLine Citation:
PMID:  15120958     Owner:  NLM     Status:  MEDLINE    
Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal mucosa of many animals. I-FABP appears in the circulation following epithelial damage, and in humans, is proven to be a parameter for damage to the mucosa. In this paper, an ELISA test designed for human I-FABP analysis was used to assay pig blood samples. The test recognized I-FABP cloned from pig small intestine and expressed in Escherichia coli. Furthermore, in our experimental model of (low flow) intestinal ischemia and reperfusion a significant rise in plasma I-FABP concentrations 15-30 min after clamping of the mesenteric artery was demonstrated. This is the first report that in pigs circulating I-FABP is a useful marker for (mild) intestinal injury, and could possibly be used to monitor (intestinal) health in clinical practice.
T A Niewold; M Meinen; J van der Meulen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in veterinary science     Volume:  77     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-91     Citation Subset:  IM    
Animal Sciences Group, Division of Animal Resources Development, Research Group Animal Physiology and Health, P.O. Box 65, 8200 AB Lelystad, The Netherlands.
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MeSH Terms
Carrier Proteins / blood*
Enzyme-Linked Immunosorbent Assay / veterinary
Fatty Acid-Binding Proteins
Intestinal Mucosa / blood supply*
Mesenteric Artery, Superior
Reperfusion Injury / blood,  veterinary*
Swine Diseases / blood*
Reg. No./Substance:
0/Carrier Proteins; 0/Fatty Acid-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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