| Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase following intestinal ischemia in pigs. | |
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MedLine Citation:
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PMID: 15120958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal mucosa of many animals. I-FABP appears in the circulation following epithelial damage, and in humans, is proven to be a parameter for damage to the mucosa. In this paper, an ELISA test designed for human I-FABP analysis was used to assay pig blood samples. The test recognized I-FABP cloned from pig small intestine and expressed in Escherichia coli. Furthermore, in our experimental model of (low flow) intestinal ischemia and reperfusion a significant rise in plasma I-FABP concentrations 15-30 min after clamping of the mesenteric artery was demonstrated. This is the first report that in pigs circulating I-FABP is a useful marker for (mild) intestinal injury, and could possibly be used to monitor (intestinal) health in clinical practice. |
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Authors:
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T A Niewold; M Meinen; J van der Meulen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in veterinary science Volume: 77 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2004-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 89-91 Citation Subset: IM |
Affiliation:
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Animal Sciences Group, Division of Animal Resources Development, Research Group Animal Physiology and Health, P.O. Box 65, 8200 AB Lelystad, The Netherlands. theo.niewold@wur.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / blood* Enzyme-Linked Immunosorbent Assay / veterinary Fatty Acid-Binding Proteins Intestinal Mucosa / blood supply* Male Mesenteric Artery, Superior Reperfusion Injury / blood, veterinary* Swine Swine Diseases / blood* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Fatty Acid-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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