| Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6. | |
| | |
MedLine Citation:
|
PMID: 16405895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: Interleukin-18 (IL-18) is a pro-inflammatory cytokine with a central role in the inflammatory cascade. In the present study, we investigated whether patients with precocious myocardial infarction have higher plasma IL-18 concentrations than matched controls. Furthermore, the relationships between plasma IL-18 concentrations and coronary atherosclerosis, C-reactive protein (CRP), interleukin-6 (IL-6) and traditional cardiovascular risk factors were examined. METHODS AND RESULTS: Three hundred eighty-seven unselected survivors of a first myocardial infarction aged less than 60 years and 387 sex and age matched controls were enrolled in the study. A subset of patients (n=236) was evaluated by quantitative coronary angiography. Postinfarction patients had significantly higher mean level of plasma IL-18 than controls (309.6+/-138.6 versus 285.4+/-115.7pg IL-18/mL). Furthermore, plasma IL-18 concentration was significantly associated with coronary plaque area (r=0.17, p=0.009). This relationship remained in a partial correlation analysis adjusting for CRP (r=0.15, p=0.02), for IL-6 (r=0.15, p=0.02) and for both CRP and IL-6 (r=0.15, p=0.02). In addition, IL-18 levels were significantly associated with other cardiovascular risk factors, namely age, low density lipoprotein (LDL) cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, insulin, proinsulin, body mass index (BMI), systolic and diastolic blood pressure. CONCLUSION: The present work provides evidence that plasma IL-18 is increased in postinfarction patients and is associated with coronary atherosclerosis. |
| | |
Authors:
|
Johannes Hulthe; William McPheat; Ann Samnegård; Per Tornvall; Anders Hamsten; Per Eriksson |
Related Documents
:
|
1750115 - Coronary heart disease and coronary risk profile in a primitive population. 6386225 - Thirty-five years of progress in cardiovascular research. 19797975 - Low high-density lipoprotein predicts death in patients with mild left ventricular dysf... 11792135 - Effects of pravastatin on mortality in patients with and without coronary heart disease... 8794525 - Release of tissue plasminogen activator during reperfusion after different times of isc... 19301285 - Regional pericarditis: a review of the pericardial manifestations of acute myocardial i... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-06 |
Journal Detail:
|
Title: Atherosclerosis Volume: 188 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-04 Completed Date: 2007-01-05 Revised Date: 2008-01-04 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 450-4 Citation Subset: IM |
Affiliation:
|
Discovery Medicine, AstraZeneca, Mölndal, Sweden; Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gothenburg, Sweden. Johannes.Hulthe@astrazeneca.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Blood Pressure Body Mass Index C-Reactive Protein / analysis* Cholesterol / blood Coronary Angiography Coronary Artery Disease / blood* Female Humans Insulin / blood Interleukin-18 / blood* Interleukin-6 / blood* Male Middle Aged Myocardial Infarction / blood* Nephelometry and Turbidimetry Risk Factors Sweden |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-18; 0/Interleukin-6; 11061-68-0/Insulin; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
|
Atherosclerosis. 2007 Dec;195(2):415-6
[PMID:
17499253
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo.
Next Document: Differential response of vascular smooth muscle cells to oxidized LDL in mouse strains with differen...