Document Detail


Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6.
MedLine Citation:
PMID:  16405895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Interleukin-18 (IL-18) is a pro-inflammatory cytokine with a central role in the inflammatory cascade. In the present study, we investigated whether patients with precocious myocardial infarction have higher plasma IL-18 concentrations than matched controls. Furthermore, the relationships between plasma IL-18 concentrations and coronary atherosclerosis, C-reactive protein (CRP), interleukin-6 (IL-6) and traditional cardiovascular risk factors were examined. METHODS AND RESULTS: Three hundred eighty-seven unselected survivors of a first myocardial infarction aged less than 60 years and 387 sex and age matched controls were enrolled in the study. A subset of patients (n=236) was evaluated by quantitative coronary angiography. Postinfarction patients had significantly higher mean level of plasma IL-18 than controls (309.6+/-138.6 versus 285.4+/-115.7pg IL-18/mL). Furthermore, plasma IL-18 concentration was significantly associated with coronary plaque area (r=0.17, p=0.009). This relationship remained in a partial correlation analysis adjusting for CRP (r=0.15, p=0.02), for IL-6 (r=0.15, p=0.02) and for both CRP and IL-6 (r=0.15, p=0.02). In addition, IL-18 levels were significantly associated with other cardiovascular risk factors, namely age, low density lipoprotein (LDL) cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, insulin, proinsulin, body mass index (BMI), systolic and diastolic blood pressure. CONCLUSION: The present work provides evidence that plasma IL-18 is increased in postinfarction patients and is associated with coronary atherosclerosis.
Authors:
Johannes Hulthe; William McPheat; Ann Samnegård; Per Tornvall; Anders Hamsten; Per Eriksson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-06
Journal Detail:
Title:  Atherosclerosis     Volume:  188     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2007-01-05     Revised Date:  2008-01-04    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  450-4     Citation Subset:  IM    
Affiliation:
Discovery Medicine, AstraZeneca, Mölndal, Sweden; Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Gothenburg, Sweden. Johannes.Hulthe@astrazeneca.com
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Blood Pressure
Body Mass Index
C-Reactive Protein / analysis*
Cholesterol / blood
Coronary Angiography
Coronary Artery Disease / blood*
Female
Humans
Insulin / blood
Interleukin-18 / blood*
Interleukin-6 / blood*
Male
Middle Aged
Myocardial Infarction / blood*
Nephelometry and Turbidimetry
Risk Factors
Sweden
Chemical
Reg. No./Substance:
0/Interleukin-18; 0/Interleukin-6; 11061-68-0/Insulin; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
Atherosclerosis. 2007 Dec;195(2):415-6   [PMID:  17499253 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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