Document Detail

Plasma interleukin-1beta concentration is associated with stroke in sickle cell disease.
MedLine Citation:
PMID:  19900820     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participated in the multi-center stroke prevention (STOP) study, to determine if plasma inflammatory protein concentration is associated with the outcome of stroke. Thirty-nine plasma samples from HbSS participants with elevated TCD who had no stroke, HbSS-NS (n=13) or had stroke, HbSS-S (n=13), HbSS steady-state controls (n=7) and controls with normal hemoglobin, HbAA (n=6), were analyzed simultaneously for 27 circulating inflammatory proteins. Logistic regression and receiver operating characteristics curve analysis of stroke on plasma inflammatory mediator concentration, adjusted for age and gender, demonstrated that interleukin-1beta (IL-1beta) was protective against stroke development (HbSS-NS=19, 17-23, HbSS-S=17, 16-19 pg/mL, median and 25th-75th percentile; odds ratio=0.59, C.I.=0.36-0.96) and was a good predictor of stroke (area under curve=0.852). This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1beta concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS.
Kwaku Asare; Beatrice E Gee; Jonathan K Stiles; Nana O Wilson; Adel Driss; Alexander Quarshie; Robert J Adams; Abdullah Kutlar; Jacqueline M Hibbert
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-11-08
Journal Detail:
Title:  Cytokine     Volume:  49     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-04-05     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Anemia, Sickle Cell* / blood,  complications,  immunology
Blood Flow Velocity
Cerebrovascular Circulation
Child, Preschool
Interleukin-1beta / blood*,  immunology
Logistic Models
ROC Curve
Regional Blood Flow
Stroke* / blood,  etiology,  immunology
Ultrasonography, Doppler, Transcranial
Young Adult
Grant Support
5R90HG004151-03/HG/NHGRI NIH HHS; G12 RR003034/RR/NCRR NIH HHS; G12 RR003034-226592/RR/NCRR NIH HHS; G12-RR03034/RR/NCRR NIH HHS; P20 RR011104/RR/NCRR NIH HHS; P20 RR011104-060008/RR/NCRR NIH HHS; P20-RR11104/RR/NCRR NIH HHS; R25 GM058268/GM/NIGMS NIH HHS; R25 RR017694/RR/NCRR NIH HHS; R90 HG004151/HG/NHGRI NIH HHS; R90 HG004151-03/HG/NHGRI NIH HHS; RR033062/RR/NCRR NIH HHS; S06 GM008248/GM/NIGMS NIH HHS; S06 GM008248/GM/NIGMS NIH HHS; S06 GM008248-13/GM/NIGMS NIH HHS; U54 RR026137/RR/NCRR NIH HHS
Reg. No./Substance:

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