| Plasma inhibition of lymphocyte proliferation in nephrotic syndrome: correlation with hyperlipidemia. | |
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MedLine Citation:
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PMID: 7142366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma-mediated inhibition of normal lymphoproliferation is an unexplained immunologic abnormality frequently observed in nephrotic syndrome. Since hyperlipidemia, also common in nephrotic syndrome, has been linked with in vitro and in vivo immunodeficiency in other diseases, we have quantitated plasma-mediated inhibition of lymphoproliferation and related it to the degree of hyperlipidemia in 19 patients with nephrotic syndrome. Fifteen patients were hyperlipidemic; the plasma of 9 of these 15 caused greater than 60% inhibition of antigen-specific proliferative responses of normal lymphocytes. None of the four normolipidemic plasmas, nor a hyperlipidemic plasma depleted of lipoproteins by ultracentrifugation, was inhibitory. A highly significant correlation between the degree of inhibition and the plasma triglyceride levels in patients with nephrotic syndrome was observed (P less than 0.001). The results suggest that elevated plasma lipids may be the cause of the plasma-mediated inhibition of lymphoproliferation in nephrotic syndrome. |
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Authors:
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C Lenarsky; S C Jordan; S Ladisch |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical immunology Volume: 2 ISSN: 0271-9142 ISO Abbreviation: J. Clin. Immunol. Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 276-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Humans Hyperlipidemias / blood, complications, immunology* Immune Tolerance Infant Lymphocyte Activation* Nephrotic Syndrome / blood, complications, immunology* Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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CA00821/CA/NCI NIH HHS; CA27701/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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