Document Detail

Plasma homocysteine thiolactone adducts associated with risk of coronary heart disease.
MedLine Citation:
PMID:  16111668     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Homocysteine thiolactone adducts have been proposed as the culprit of homocysteine related cardiovascular diseases. We studied the association of these adducts in plasma, and the gene polymorphism of paraoxonase-2 with coronary heart disease. METHODS: 254 patients and 308 controls were recruited for the study. Homocysteine thiolactone adducts were determined with ELISA. The codon 311 polymorphism of paraoxonase-2 gene was genotyped by using polymerase chain reaction and restrictive digestion. RESULTS: The plasma level of homocysteine thiolactone adducts were significantly higher in patients than in controls (40.65 +/- 10.87 u/ml vs. 30.58 +/- 10.20 u/ml, P <0.01), with odds ratio of 7.34 (95% confidence interval 4.020-13.406, P <0.01), and increased according to the number of atherosclerotic coronary arteries: 35.59 +/- 10.34 units/ml (n = 76); 41.88 +/- 8.83 (n = 70) and 43.13 +/- 11.47 (n = 108) in subjects with 1, 2 and 3 affected arteries, respectively (r =0.174, P < 0.01). The frequency of CC genotype was significantly higher in patients with coronary heart disease (7.48%) than in controls (1.62%, P < 0.01), with adjusted odds ratio of 4.367 (95% confidence interval: 1.178 to 16.191, P < 0.01), so was the C allele (23.2% vs. 14.9%, P < 0.05). CONCLUSIONS: High plasma homocysteine thiolactone adducts and the CC 311 genotype of paraoxonase-2 gene may be the emerging risk factor for coronary heart disease.
Xu Yang; Yan Gao; Jin Zhou; Yisong Zhen; Yuejin Yang; Jizheng Wang; Li Song; Yuqing Liu; Haiyan Xu; Zaijia Chen; Rutai Hui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-18
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  364     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, PR China.
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MeSH Terms
Aryldialkylphosphatase / genetics
Coronary Disease / blood*,  enzymology,  genetics
Enzyme-Linked Immunosorbent Assay
Gene Frequency
Homocysteine / analogs & derivatives*,  blood
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Reg. No./Substance:
10593-85-8/homocysteine thiolactone; 454-28-4/Homocysteine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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