Document Detail


Plasma histamine in patients with chronic renal failure and nephrotic syndrome.
MedLine Citation:
PMID:  2013627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to glomerular capillaries and arterial endothelium. Plasma histamine concentrations were significantly increased in all four patient groups when compared with those of controls and were the highest in two patients with pruritus. Raised plasma histamine concentrations in such patients are consistent with the hypothesis that histamine may contribute to the damage to glomerular capillaries and to arterial endothelium. These effects may be relevant to the pathogenesis of glomerular disease and atherosclerosis. Histamine may also contribute to the pathogenesis of pruritus in patients with chronic renal failure.
Authors:
D S Gill; V A Fonseca; M A Barradas; R Balliod; J F Moorhead; P Dandona
Related Documents :
9578897 - Immunosuppression and outcome in idiopathic membranous nephropathy.
22672827 - Quantitative analysis of intestinal gas in patients with acute pancreatitis.
8255007 - Effect of the angiotensin converting enzyme inhibitor, captopril, on proteinuria in chr...
7034297 - Immunofluorescent studies on acute phase reactants in patients with various types of ch...
4045557 - Clinical significance of solitary rib lesions in patients with extraskeletal malignancy.
12923337 - Paradoxical therapy in conversion reaction.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  44     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-05-14     Completed Date:  1991-05-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  243-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital, London.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Female
Histamine / blood*
Humans
Kidney Failure, Chronic / blood*,  therapy
Male
Middle Aged
Nephrotic Syndrome / blood*,  therapy
Peritoneal Dialysis, Continuous Ambulatory
Pruritus / blood,  complications
Radioimmunoassay
Renal Dialysis
Vascular Diseases / blood,  complications
Chemical
Reg. No./Substance:
51-45-6/Histamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Automated microparticle enzyme immunoassays for IgG and IgM antibodies to Toxoplasma gondii.
Next Document:  Lack of specificity for antibodies to double stranded DNA found in four commercial kits.