Document Detail

Plasma histamine in patients with chronic renal failure and nephrotic syndrome.
MedLine Citation:
PMID:  2013627     Owner:  NLM     Status:  MEDLINE    
Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to glomerular capillaries and arterial endothelium. Plasma histamine concentrations were significantly increased in all four patient groups when compared with those of controls and were the highest in two patients with pruritus. Raised plasma histamine concentrations in such patients are consistent with the hypothesis that histamine may contribute to the damage to glomerular capillaries and to arterial endothelium. These effects may be relevant to the pathogenesis of glomerular disease and atherosclerosis. Histamine may also contribute to the pathogenesis of pruritus in patients with chronic renal failure.
D S Gill; V A Fonseca; M A Barradas; R Balliod; J F Moorhead; P Dandona
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  44     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-05-14     Completed Date:  1991-05-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  243-5     Citation Subset:  AIM; IM    
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital, London.
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MeSH Terms
Histamine / blood*
Kidney Failure, Chronic / blood*,  therapy
Middle Aged
Nephrotic Syndrome / blood*,  therapy
Peritoneal Dialysis, Continuous Ambulatory
Pruritus / blood,  complications
Renal Dialysis
Vascular Diseases / blood,  complications
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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