Document Detail


Plasma high-density lipoprotein cholesterol: association with measurements of body mass. The Lipid Research Clinics Program Prevalence Study.
MedLine Citation:
PMID:  7418145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Relationships between weight, height and ponderal indexes and plasma high-density lipoprotein (HDL) cholesterol and triglyceride were assessed by the Lipid Research Clinics Prevalence Study for 6865 white children and adults (3517 males and 3348 females). Overall, weight, weight/height, weight/height and weight/height were significantly and inversely associated with plasma HDL cholesterol levels and positively associated with plasma triglyceride levels. When the relationships of Quetelet index (weight/height) to HDL cholesterol were assessed by multiple regression analysis, including the explanatory variables of cigarette smoking, alcohol intake and exogenous estrogen hormone use, the Quetelet index was significantly and inversely associated with HDL cholesterol levels in children (by age 12-16 years) and adults of both sexes. After covariance adjustment for smoking, alcohol intake, hormone use and age, mean HDL cholesterol levels for individuals at the Quetelet tenth percentile were 3 mg/dl higher than for those at the fiftieth percentile, and these in turn were 3-4 mg/dl higher than for those at the ninetieth percentile. These differences in HDL cholesterol differences reported to be related to coronary heart disease mortality. Improved approaches to the primary prevention of atherosclerosis may be realized by a better understanding of the inverse relationship of body mass to HDL cholesterol levels.
Authors:
C J Glueck; H L Taylor; D Jacobs; J A Morrison; R Beaglehole; O D Williams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  62     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  IV-62-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aging
Body Height
Body Weight
Child
Child, Preschool
Cholesterol / blood*
Female
Humans
Lipids
Lipoproteins, HDL / blood*
Male
Middle Aged
Research
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
N01-HV1-2156-L/HV/NHLBI NIH HHS; N01-HV1-2160-L/HV/NHLBI NIH HHS; N01-HV2-2914-L/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipids; 0/Lipoproteins, HDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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