| Plasma granzyme B as a predicting factor of coronary artery disease--clinical significance in patients with chronic renal failure. | |
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MedLine Citation:
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PMID: 19944316 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: To elucidate the role of granzyme B in coronary artery disease (CAD) in patients with chronic kidney disease (CKD). We hypothesized that granzyme B plays an important role in the formation of coronary artery lesions in patients with CKD. PATIENTS AND METHODS: We studied 141 patients (116 men and 25 women; mean age, 64.2±9.6 years) and 16 control subjects. Diagnosis of CAD was confirmed by selective coronary angiography. CKD was defined as a sustained decrease in the estimated glomerular filtration (eGFR) rate less than 60 mL/min/1.73 m(2) over 3 months. We assigned patients to three groups: CAD without CKD (CAD group, n=46), CKD without CAD (CKD group, n=18), and CAD with CKD (CAD/CKD group, n=77). Plasma granzyme B was measured by enzyme-linked immunosorbent assay. Factors contributing to the severity of CAD were analyzed by multiple regression analysis in patients with CAD. RESULTS: Plasma levels of high-sensitivity CRP (hs-CRP) and granzyme B in the CAD/CKD group were significantly higher than in other groups. A significant positive correlation was observed between plasma hs-CRP and granzyme B levels. A significant negative correlation was observed between eGFR and granzyme B levels. Multiple regression analysis revealed that granzyme B and hs-CRP levels were independent predicting variables of the number of stenoses in major coronary arteries. CONCLUSIONS: These results indicate that granzyme B might be a novel risk factor for the formation of coronary atherosclerosis by inducing apoptosis of vascular tissues in patients with CKD. |
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Authors:
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Tomokazu Ikemoto; Yukihiro Hojo; Hideyuki Kondo; Nozomu Takahashi; Masahiro Hirose; Yoshioki Nishimura; Takaaki Katsuki; Kazuyuki Shimada |
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Publication Detail:
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Type: Journal Article Date: 2009-08-07 |
Journal Detail:
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Title: Journal of cardiology Volume: 54 ISSN: 1876-4738 ISO Abbreviation: J Cardiol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 409-15 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Jichi Medical University, 3311 Yakushiji, Shimotsuke-City, Tochigi 329-0498, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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