Document Detail


Plasma granzyme B as a predicting factor of coronary artery disease--clinical significance in patients with chronic renal failure.
MedLine Citation:
PMID:  19944316     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVES: To elucidate the role of granzyme B in coronary artery disease (CAD) in patients with chronic kidney disease (CKD). We hypothesized that granzyme B plays an important role in the formation of coronary artery lesions in patients with CKD.
PATIENTS AND METHODS: We studied 141 patients (116 men and 25 women; mean age, 64.2±9.6 years) and 16 control subjects. Diagnosis of CAD was confirmed by selective coronary angiography. CKD was defined as a sustained decrease in the estimated glomerular filtration (eGFR) rate less than 60 mL/min/1.73 m(2) over 3 months. We assigned patients to three groups: CAD without CKD (CAD group, n=46), CKD without CAD (CKD group, n=18), and CAD with CKD (CAD/CKD group, n=77). Plasma granzyme B was measured by enzyme-linked immunosorbent assay. Factors contributing to the severity of CAD were analyzed by multiple regression analysis in patients with CAD.
RESULTS: Plasma levels of high-sensitivity CRP (hs-CRP) and granzyme B in the CAD/CKD group were significantly higher than in other groups. A significant positive correlation was observed between plasma hs-CRP and granzyme B levels. A significant negative correlation was observed between eGFR and granzyme B levels. Multiple regression analysis revealed that granzyme B and hs-CRP levels were independent predicting variables of the number of stenoses in major coronary arteries.
CONCLUSIONS: These results indicate that granzyme B might be a novel risk factor for the formation of coronary atherosclerosis by inducing apoptosis of vascular tissues in patients with CKD.
Authors:
Tomokazu Ikemoto; Yukihiro Hojo; Hideyuki Kondo; Nozomu Takahashi; Masahiro Hirose; Yoshioki Nishimura; Takaaki Katsuki; Kazuyuki Shimada
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Publication Detail:
Type:  Journal Article     Date:  2009-08-07
Journal Detail:
Title:  Journal of cardiology     Volume:  54     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  409-15     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Jichi Medical University, 3311 Yakushiji, Shimotsuke-City, Tochigi 329-0498, Japan.
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