| Plasma glucose after stomach or jejunum glucose infusion in roux-en-y gastric bypass patients - a possible implication for early satiety mechanism. | |
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MedLine Citation:
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PMID: 21374542 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Morbidly obese patients undergoing gastric bypass surgery experience early satiety soon after the surgery; the mechanism of this effect is poorly understood. As blood glucose concentration plays a role in appetite regulation in humans, we hypothesized that after gastric bypass surgery glucose absorbed mainly in jejunum leads to a greater rise in plasma glucose that if it is ingested in stomach. MATERIAL AND METHODS: 24 non-diabetes morbidly obese patients (15 women, 9 men, mean age [±SD] 35.6±11.9 years, body weight 140.7±33.1 kg, BMI 46.8±8.3 kg/m (2)) undergoing Roux-en-Y gastric bypass surgery were given 10 ml of 40% glucose solution to the stomach before its size reduction and to the jejunum after gastro-jejunal anastomosis was formed. RESULTS: After jejunal infusion blood glucose increased more rapidly and was ∼30% higher than after stomach infusion. Moreover, this increase was less pronounced in more obese patients. CONCLUSION: In patients after Roux-en-Y gastric bypass surgery glucose absorbed in jejunum leads to greater rise in plasma glucose concentration than if it is ingested in stomach. This phenomenon may help explain satiety feeling occurring early in gastric bypass surgery patients. |
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Authors:
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L Czupryniak; M Pawłowski; D Szymański; W Olejniczak; M Saryusz-Wolska; J Loba; J Strzelczyk |
Publication Detail:
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Type: Journal Article Date: 2011-03-03 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 119 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Copyright Information:
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Department of Internal Medicine and Diabetology, Barlicki University Hospital No 1, Medical University of Lodz, Lodz, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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