Document Detail


Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis.
MedLine Citation:
PMID:  18057384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Type 1 diabetes mellitus patients (DM1) show increased prevalence of pernicious anaemia, the histological substrate of which is type A chronic atrophic gastritis (CAG) in the stomach corpus, the main source of ghrelin. We aimed to compare plasma ghrelin concentrations in DM1 patients with type A CAG (DM1-CAG), DM1 patients without type A CAG and healthy controls and in DM1-CAG group, to ascertain a possible relationship between ghrelin and biochemical markers of gastric mucosa atrophy and/or neuroendocrine (NE) cell hyperplasia and histological gastric biopsy findings. DESIGN AND METHODS: Fifteen DM1-CAG patients were matched for age, sex and body mass index with 15 DM1 patients without type A CAG and 15 controls. Pepsinogen I, pepsinogen II, gastrin, parietal cell antibodies, chromogranin A (CgA) and ghrelin were determined in all subjects. In DM1-CAG patients, immunohistochemical analysis of gastric biopsies using antibodies to CgA and ghrelin was performed. RESULTS: Ghrelin concentrations differed among groups; however, paired comparisons between groups were not significant. In DM1-CAG, no correlation was found between ghrelin and gastric body atrophy markers, pepsinogen I and the pepsinogen I/II ratio. Immunohistochemical studies of DMI-CAG patients showed CgA staining in 12 and ghrelin staining in 6, which was confined to the foci of NE cell hyperplasia. Those patients who stained positive for ghrelin had higher ghrelin concentrations when compared with the negative patients. CONCLUSIONS: Ghrelin concentrations are not decreased in DM1-CAG patients; thus, our data suggest that ghrelin is not a good marker of gastric mucosa atrophy in these patients, given the possible ghrelin synthesis in hyperplastic gastric endocrine/enterochromaffin-like cells.
Authors:
Núria Alonso; María Luisa Granada; Isabel Salinas; Jorge Luis Reverter; Lilliam Flores; Isabel Ojanguren; Eva María Martínez-Cáceres; Anna Sanmartí
Related Documents :
11743254 - Nutritional problems in end-stage liver disease: contribution of impaired gastric empty...
15946444 - Topical benzocaine (hurricaine) induced methemoglobinemia during endoscopic procedures ...
21719424 - Vitamin d levels in chinese patients with systemic lupus erythematosus: relationship wi...
9849494 - Effects of ondansetron on gastrointestinal symptoms in carcinoid syndrome.
17505034 - Cd4-regulatory cells in copd patients.
23112564 - Severe acute cholangitis after endoscopic sphincterotomy induced by barium examination:...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  157     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  763-9     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Ctra Canyet s/n, Badalona 08916, Barcelona, Spain. nalonso.germanstrias@gencat.net
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Autoimmune Diseases / blood*,  pathology
Diabetes Mellitus, Type 1 / blood*,  complications
Female
Gastric Mucosa / pathology
Gastritis, Atrophic / blood*,  etiology,  pathology
Ghrelin / blood*
Helicobacter Infections / blood
Helicobacter pylori
Humans
Hyperplasia / pathology
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Ghrelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three p...
Next Document:  Food-dependent Cushing's syndrome: from molecular characterization to therapeutical results.