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Plasma free fatty acid reference interval in South African neonates in the first week of life.
MedLine Citation:
PMID:  20592337     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Non-esterified fatty acid (NEFA) levels are an important diagnostic tool in the investigation of neonatal hypoglycaemia. NEFA reference intervals have not been reported for neonates previously.
METHODS: The objective of this study was to determine an NEFA reference interval for neonates.
RESULTS: Heparinized plasma obtained from 106 healthy neonates in the first week of life was analysed using the Roche "Free fatty acid, Half-micro test" kit. Results were then analysed statistically for normality (Shapiro-Wilk test) and reference interval determined non-parametrically (bootstrap method).
CONCLUSIONS: NEFA levels displayed a non-Gaussian distribution and the reference interval (2.5th and 97.5th percentiles) was 0.2-1.5 mmol/L (90% confidence intervals 0.1-0.3 and 1.4-2.0 mmol/L, respectively). The NEFA reference interval in South African neonates less than a week old is similar to that described in infants (1-12 months), indicating that this reference range can be used over the entire neonatal period.
Authors:
F Omar; G van der Watt; V November; T S Pillay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  47     ISSN:  1758-1001     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  381-2     Citation Subset:  IM    
Affiliation:
Department of Clinical Laboratory Sciences, Division of Chemical Pathology, University of Cape Town and National Health Laboratory Service, Groote Schuur & Red Cross Children's Hospital, Cape Town, South Africa.
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