Document Detail


Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine.
MedLine Citation:
PMID:  9665436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We established the cutoff value for plasma folic acid, using plasma homocyst(e)ine as the functional marker. To do this, we investigated the relationship of the plasma folic acid of 103 apparently healthy adults with their fasting plasma homocyst(e)ine and with their plasma homocyst(e)ine 6 h after oral methionine challenge (100 mg/kg). We also studied the relationship of their plasma folic acid with the decline of fasting plasma homocyst(e)ine after 7 days of folic acid supplementation (5 mg/day). The three approaches suggested a cutoff value of 10 nmol/L. The chances of individuals to significantly (P <0.05) lower their plasma homocyst(e)ine after folic acid supplementation proved significantly higher at plasma folic acid concentrations < or = 10 nmol/L, as compared with folic acid concentrations above this value (odds ratio, 5.02; 95% confidence interval, 1.87-13.73). We suggest adopting a 10 nmo/L plasma folic acid cutoff value on functional grounds.
Authors:
D A Brouwer; H T Welten; D J Reijngoud; J J van Doormaal; F A Muskiet
Related Documents :
15991886 - Lubiprostone: ru 0211, spi 0211.
2105296 - Methanogenesis involving a novel carrier of c1 compounds in methanogenium tationis.
10588216 - Folic acid improves arterial endothelial function in adults with hyperhomocystinemia.
18238826 - Economic evaluation of folic acid food fortification in the netherlands.
18095926 - Liposome-nucleic acid immunotherapeutics.
12868936 - New pyrazolium-carboxylates as structural analogues of the pseudo-cross-conjugated beta...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  44     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-23     Completed Date:  1998-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1545-50     Citation Subset:  IM    
Affiliation:
Central Laboratory for Clinical Chemistry, Groningen University Hospital, The Netherlands. d.a.j.brouwer@lab.azg.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Fasting
Folic Acid / administration & dosage,  blood*
Homocysteine / blood*
Humans
Methionine / diagnostic use
Middle Aged
Pyridoxine / administration & dosage
Reference Values
Chemical
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Water, fat, nitrogen, and sugar content in feces: reference intervals in children.
Next Document:  Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-...