Document Detail

Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine.
MedLine Citation:
PMID:  9665436     Owner:  NLM     Status:  MEDLINE    
We established the cutoff value for plasma folic acid, using plasma homocyst(e)ine as the functional marker. To do this, we investigated the relationship of the plasma folic acid of 103 apparently healthy adults with their fasting plasma homocyst(e)ine and with their plasma homocyst(e)ine 6 h after oral methionine challenge (100 mg/kg). We also studied the relationship of their plasma folic acid with the decline of fasting plasma homocyst(e)ine after 7 days of folic acid supplementation (5 mg/day). The three approaches suggested a cutoff value of 10 nmol/L. The chances of individuals to significantly (P <0.05) lower their plasma homocyst(e)ine after folic acid supplementation proved significantly higher at plasma folic acid concentrations < or = 10 nmol/L, as compared with folic acid concentrations above this value (odds ratio, 5.02; 95% confidence interval, 1.87-13.73). We suggest adopting a 10 nmo/L plasma folic acid cutoff value on functional grounds.
D A Brouwer; H T Welten; D J Reijngoud; J J van Doormaal; F A Muskiet
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  44     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-23     Completed Date:  1998-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1545-50     Citation Subset:  IM    
Central Laboratory for Clinical Chemistry, Groningen University Hospital, The Netherlands.
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MeSH Terms
Aged, 80 and over
Folic Acid / administration & dosage,  blood*
Homocysteine / blood*
Methionine / diagnostic use
Middle Aged
Pyridoxine / administration & dosage
Reference Values
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine; 65-23-6/Pyridoxine

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