| Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine. | |
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MedLine Citation:
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PMID: 9665436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We established the cutoff value for plasma folic acid, using plasma homocyst(e)ine as the functional marker. To do this, we investigated the relationship of the plasma folic acid of 103 apparently healthy adults with their fasting plasma homocyst(e)ine and with their plasma homocyst(e)ine 6 h after oral methionine challenge (100 mg/kg). We also studied the relationship of their plasma folic acid with the decline of fasting plasma homocyst(e)ine after 7 days of folic acid supplementation (5 mg/day). The three approaches suggested a cutoff value of 10 nmol/L. The chances of individuals to significantly (P <0.05) lower their plasma homocyst(e)ine after folic acid supplementation proved significantly higher at plasma folic acid concentrations < or = 10 nmol/L, as compared with folic acid concentrations above this value (odds ratio, 5.02; 95% confidence interval, 1.87-13.73). We suggest adopting a 10 nmo/L plasma folic acid cutoff value on functional grounds. |
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Authors:
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D A Brouwer; H T Welten; D J Reijngoud; J J van Doormaal; F A Muskiet |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical chemistry Volume: 44 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-07-23 Completed Date: 1998-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1545-50 Citation Subset: IM |
Affiliation:
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Central Laboratory for Clinical Chemistry, Groningen University Hospital, The Netherlands. d.a.j.brouwer@lab.azg.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Fasting Folic Acid / administration & dosage, blood* Homocysteine / blood* Humans Methionine / diagnostic use Middle Aged Pyridoxine / administration & dosage Reference Values |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine; 65-23-6/Pyridoxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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