| Plasma fibronectin concentration in patients with acquired consumptive coagulopathies. | |
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MedLine Citation:
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PMID: 6523449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma fibronectin was assayed in 179 hospitalized patients referred for workup of possible acquired coagulopathy. Based on laboratory results and chart review, these patients were classified as having no coagulopathy (N = 36), defibrination syndrome (N = 31), compensated defibrination syndrome (N = 100), microangiopathic thrombocytopenia (N = 7), and primary fibrinolysis (N = 5). Compared to patients with no coagulopathy, fibronectin concentration was reduced in patients with defibrination syndrome (p less than 0.005) and compensated defibrination syndrome (p less than 0.10). Fibronectin concentration was not reduced in patients with microangiopathic thrombocytopenia and primary fibrinolysis. In patients with defibrination syndrome, the reduction of fibronectin was correlated to the degree of liver impairment. This finding is consistent with the liver being the primary site of synthesis of plasma fibronectin. Fibronectin was significantly correlated to plasminogen and antithrombin III. The sensitivity of fibronectin for the diagnosis of coagulopathy is low except for patients with defibrination syndrome. |
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Authors:
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G S Cembrowski; D F Mosher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Thrombosis research Volume: 36 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-03-07 Completed Date: 1985-03-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 437-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antithrombin III
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analysis Disseminated Intravascular Coagulation / blood* Fibrinogen / analysis Fibrinolysis Fibronectins / blood* Humans Plasminogen / analysis Platelet Count Thrombocytopenia / blood |
| Grant Support | |
ID/Acronym/Agency:
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HL 21644/HL/NHLBI NIH HHS; HL 24885/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 9000-94-6/Antithrombin III; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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