Document Detail


Plasma fatty acids of marrow transplant recipients on fat-supplemented parenteral nutrition.
MedLine Citation:
PMID:  6424428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study was conducted to determine the adequacy of fat infusion in preventing essential fatty acid deficiency during parenteral feeding. Eight adult patients receiving marrow transplantation for the treatment of leukemia were studied. Total daily intravenous and oral calorie and fat intakes were monitored. Insignificant amounts of food were consumed orally during the 30-day study period. Parenteral nutrition, initiated pretransplant, included 250 ml of 10% fat infusion daily. Plasma total fatty acids were determined by gas-liquid chromatography at specified intervals to detect biochemical essential fatty acid deficiency. The results showed a rapid and significant decline of linoleic acid, 18:2 omega 6, as percentage of total fatty acids. The arachidonic acid, 20:4 omega 6, was not significantly altered. The abnormal fatty acid, eicosatrienoic acid, 20:3 omega 9, was found in trace amounts in five patients. None of the patients developed a 20:3 omega 9/20:4 omega 6 ratio of 0.2 or more. The level of fat infused prevented biochemical essential fatty acid deficiency, but the plasma fatty acid profile was significantly different from normal levels.
Authors:
W K Yamanaka; G Tilmont; S N Aker
Related Documents :
3321088 - Essential fatty acid consideration at birth in the premature neonate and the specific r...
6494498 - The effects of di- and trichloroacetic acid on sheep erythrocytes: an animal model with...
12514918 - Taurine: a conditionally essential amino acid in humans? an overview in health and dise...
10501288 - Plasma fatty acids concentrations in postoperative patients with biliary atresia.
22338078 - Bed rest impairs skeletal muscle amino acid transporter expression, mtorc1 signaling, a...
23055338 - Application of high throughput pretreatment and co-hydrolysis system to thermochemical ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  39     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  607-11     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Marrow Transplantation*
Fat Emulsions, Intravenous / pharmacology*
Fatty Acids / blood*
Fatty Acids, Essential / blood,  deficiency
Humans
Nutritional Requirements
Parenteral Nutrition / methods*
Parenteral Nutrition, Total / methods*
Grant Support
ID/Acronym/Agency:
CA 15704/CA/NCI NIH HHS; CA 18029/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Fatty Acids, Essential

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of polyunsaturated and saturated fats on plasma lipids and lipoproteins in man.
Next Document:  Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver.