| Plasma fatty acid levels may regulate the Zn(2+)-dependent activities of histidine-rich glycoprotein. | |
| | |
MedLine Citation:
|
PMID: 19679159 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Histidine-rich glycoprotein (HRG) is a plasma adaptor protein involved in the formation of protein complexes that regulate a number of biological processes in the blood, most notably coagulation and the immune system. Elevated levels of HRG are clinically linked to thrombotic disorders such as blood vessel occlusion. A large body of evidence suggests that Zn(2+) ions stimulate HRG-complex formation; however, under normal conditions the vast majority of Zn(2+) in the blood is bound to human serum albumin (HSA). We have previously demonstrated that high levels of fatty acid act as an allosteric switch which disrupts the major Zn(2+)-binding site on HSA. Transient or sustained elevation of plasma fatty acid levels may therefore increase the proportion of plasma Zn(2+) associated with HRG. We speculate that this mechanism may potentiate an increased risk of thrombosis in individuals with elevated fatty acid levels such as those associated with cancer, obesity and diabetes. |
| | |
Authors:
|
Alan J Stewart; Claudia A Blindauer; Peter J Sadler |
Related Documents
:
|
2931099 - The transfer of free fatty acids across the human placenta. 10870849 - Lovastatin therapy for x-linked adrenoleukodystrophy: clinical and biochemical observat... 8412119 - Extremity metabolism in the cachectic, vx-2 carcinoma-bearing rabbit. 18236169 - Interpretation of plasma amino acids in the follow-up of patients: the impact of compar... 6816619 - The influence of free fatty acids on valproic acid plasma protein binding during fastin... 846309 - Absence of eicosatrienoic acid in plasma of sheep parenterally infused with a high gluc... 1292929 - Tissue-mediated regeneration of ascorbic acid: is the process enzymatic? 932249 - Ultrastructural localization of acid phosphatase in normal and x-irradiated epidermis. 15635819 - Valproic acid intoxication: sense and non-sense of haemodialysis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-11 |
Journal Detail:
|
Title: Biochimie Volume: 91 ISSN: 1638-6183 ISO Abbreviation: Biochimie Publication Date: 2009 Nov-Dec |
Date Detail:
|
Created Date: 2009-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1264604 Medline TA: Biochimie Country: France |
Other Details:
|
Languages: eng Pagination: 1518-22 Citation Subset: IM |
Affiliation:
|
Bute Medical School, University of St. Andrews, Bute Building, St. Andrews, Fife KY16 9TS, UK. ajs21@st-andrews.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dissimilarity in the channel intrinsic stability among the bacterial KcsA and the inwardly rectifyin...
Next Document: Characterization of papain-like isoenzymes from latex of Asclepias curassavica by molecular biology ...