Document Detail

Plasma exchange in Guillain-Barré syndrome: effect on anti-peripheral nerve myelin antibodies.
MedLine Citation:
PMID:  2256446     Owner:  NLM     Status:  MEDLINE    
Increased levels of anti-peripheral nerve myelin (anti-PNM) antibodies were demonstrated by ELISA in serum from 4 of 7 patients with Guillain-Barré syndrome (GBS). Treatment with plasma exchange (PE) was performed and 6 of the 7 patients showed clinical improvement with marked increase in muscular strength. One patient, however, continued to deteriorate during the treatment. No correlation between clinical improvement and levels of anti-PNM antibodies was observed. Whether the antibodies are of pathogenetic importance in GBS is therefore still unknown.
C A Vedeler; H Nyland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  82     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Department of Neurology, University of Bergen, Norway.
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MeSH Terms
Aged, 80 and over
Autoantibodies / analysis*
Enzyme-Linked Immunosorbent Assay
Middle Aged
Myelin Sheath / immunology*
Peripheral Nerves / immunology*
Plasma Exchange*
Polyradiculoneuropathy / blood,  therapy*
Reg. No./Substance:

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