| Plasma exchange as a therapeutic option in patients with neurologic symptoms due to antibodies to voltage-gated potassium channels: A report of five cases and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 22532193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Antibodies to voltage-gated potassium channels (VGKC) are associated with acquired neuromyotonia, limbic encephalitis, and Morvan's syndrome. The antibodies are often not associated with malignancy and have shown good clinical response to immunomodulatory therapies. A record review identified five patients with laboratory evidence of antibodies to VGKC who underwent plasma exchange (PE) as part of their immunosuppressive therapy for neurologic disease. Four of the patients presented with limbic encephalitis and one with neuromyotonia. Symptoms included memory impairment, seizures, and personality changes. All PE were 1.0 volume and were performed on an every-other-day schedule. Replacement fluid was 5% normal serum albumin except when a bleeding risk was identified and then fresh frozen plasma was added. Four of five patients were also receiving concurrent immunosuppressive therapy including corticosteroids. Of the five patients treated with PE, three had sustained improvement in symptoms for 6-17 months following PE. Two patients did not have signs of improvement at a limited follow-up. One patient had recurrence of her symptoms, which responded to additional PE. These cases, as well as the reports in the literature, suggest that PE could be a useful adjunctive therapy for patients with VGKC antibodies and neurologic symptoms. J. Clin. Apheresis 2012. © 2012 Wiley Periodicals, Inc. |
| | |
Authors:
|
Elizabeth A Jaben; Jeffrey L Winters |
Related Documents
:
|
22517093 - Csf biomarkers for alzheimer disease correlate with cortical brain biopsy findings. 22640663 - Structural correlates of facial emotion recognition deficits in parkinson's disease pat... 11399603 - Erythrocytes: anemias in chronic liver diseases. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-24 |
Journal Detail:
|
Title: Journal of clinical apheresis Volume: - ISSN: 1098-1101 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Laboratory Medicine and Pathology, Division of Clinical Pathology, Mayo Clinic Hospital, Phoenix, Arizona. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of repeated "benign" noise exposures in young CBA mice: shedding light on age-related hearin...
Next Document: Recruiting Researchers in Psychiatry: The Influence of Residency vs. Early Motivation.