Document Detail

Plasma erythropoietin levels in fetal and newborn rats: response to hypoxia.
MedLine Citation:
PMID:  7461059     Owner:  NLM     Status:  MEDLINE    
Plasma erythropoietin (Ep) activity was detectable in fetal rats near term and in rats less than 2 old. Ep activity was not found 12--48 h after birth. A hypoxic period (0.5 atmospheres for 6 h) increased the plasma Ep level in fetal and newborn rats, and in pregnant animals. After long-term hypoxia (0.5 atmospheres for 8 days) the plasma Ep level was neither increased in fetal rats nor in their mothers, while a compensatory increase in the hematocrit level occurred. It is concluded that hypoxia stimulates Ep production during hepatic erythropoiesis. During long-term hypoxia compensatory mechanisms for tissue oxygenation occur.
A Meberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental hematology     Volume:  8     ISSN:  0301-472X     ISO Abbreviation:  Exp. Hematol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  615-9     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn*
Anoxia / blood*
Erythropoietin / blood*
Reg. No./Substance:

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