Document Detail

Plasma nitrite/nitrate and erythropoietin levels in cross-country skiers during altitude training.
MedLine Citation:
PMID:  12032406     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the effects of training at altitude on plasma nitrite/nitrate and erythropoietin levels since previously it has been reported an interaction of the NO/cGMP system in erythropoietin production. METHODS: Nine physically trained cross-country male skiers, usually living at 800-1200 m altitude, underwent 6 days of intensive training at a moderate altitude of 3100 m preceeded by 2 days of acclimatisation. Six team-managers, selected as controls, did not undergo any regular physical activity in the last 5 years and during the altitude period. Haematological parameters, erythropoietin and nitrite/nitrate were measured prior to reach the place at altitude, at the end of the period at moderate altitude and 7 days after returning at home. RESULTS: Haematocrit significantly increased in controls after 8 days at altitude. Erythropoietin levels significantly increased after the intensive altitude training only in trained subjects (13.1+/-1.7 vs 6.7+/-1.7 mU x ml-1, p<0.001). Nitrite/nitrate baseline values were significantly higher in trained subjects compared to untrained (49.9+/-17.9 vs 25.4+/-2.8 micromol x l(-1), p<0.01); the altitude period significantly increased nitrite/nitrate levels, in untrained subjects, to the same values observed in trained subjects under control conditions (47.0+/-10.3 micromol x l(-1)). CONCLUSIONS: In our experimental conditions we demonstrated the influence of hypoxia on Epo levels in athletes sustaining a short-term training and the role of a regular physical activity (partly independent from altitude hypoxia) on NO production.
F Schena; L Cuzzolin; L Rossi; M Pasetto; G Benoni
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  42     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-28     Completed Date:  2002-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Ce.Bi.S.M., Center of Bioengineering and Motor Sciences, Rovereto (TN), Italy.
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MeSH Terms
Analysis of Variance
Anoxia / blood
Erythropoiesis / physiology*
Nitric Oxide / blood*
Physical Fitness / physiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

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