Document Detail


Plasma and erythrocyte essential fatty acids during total parenteral nutrition in infants: effects of a cutaneous supply.
MedLine Citation:
PMID:  3083136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to prevent essential fatty acid (EFA) deficiency induced by fat-free total parenteral nutrition (TPN), 10 infants on TPN were rubbed three times daily for 20 days using oenethera oil (80% EFA). Total EFA amount provided cutaneously was 1900 mg/kg/d. Plasma and red blood cells phospholipids were determined on days 1 and 20 in these 10 treated and six untreated infants on TPN and compared with those of normal control infants. On day 1, plasma nonessential FA including 20:3 n-9(p less than 0.01) were increased in both TPN groups while 18:2 n-6 and 18:3 n-3 (p less than 0.001 and p less than 0.01) were decreased. On the 20th day, EFA deficiency had worsened with a decrease in plasma level of 20:4 n-6 (p less than 0.02) and a higher than normal triene/tetraene ratio : 3.4 +/- 1.1 and 2.3 +/- 0.6 vs 0.1 +/- 0.1 (p less than 0.02). As for red blood cells phospholipids, 16:0 was increased and 18:2 n-6 and 20:3 n-6 were decreased (p less than 0.05) on day 1. On day 20, these FA were more abnormal while 20:3 n-9 became significantly increased (p less than 0.05). No difference was observed between the TPN groups at any time. These results show that cutaneous application of large amounts of EFA-rich oil is unable to prevent or cure TPN induced EFA deficiency.
Authors:
D Bougle; D Pepin; M Delhaye; J Chambaz; C Ricour
Related Documents :
23089636 - Production of nitric oxide is lower in shiga toxin-stimulated neutrophils of infants co...
24833216 - Lung ultrasound for the diagnosis of severe neonatal pneumonia.
10492416 - Plasma paracetamol concentrations and pharmacokinetics following rectal administration ...
3111166 - Stable glucose balance in premature infants with fluid restriction and early enteral fe...
7698366 - Phagocytic activity mediated via fc gamma r, fc mu r, and cr3 and h2o2 release during o...
8405036 - Pharmacokinetics of diphemanil methylsulphate in infants.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  10     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1986-05-09     Completed Date:  1986-05-09     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  216-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Topical
Erythrocytes / metabolism
Fatty Acids, Essential / administration & dosage,  blood*,  deficiency
Humans
Infant
Parenteral Nutrition, Total / adverse effects*
Skin / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Selenium content of enteral formulas.
Next Document:  Dressing changes by specialized personnel reduce infection rates in patients receiving central venou...