Document Detail


Plasma endothelin levels and surgically correctable pulmonary hypertension.
MedLine Citation:
PMID:  8431058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To know the changes in plasma endothelin of patients with pulmonary hypertension, we studied 32 patients with valvular heart disease. Among them, 22 patients had pulmonary hypertension (group I) and 10 had pulmonary arterial pressures in the normal range (group II). Plasma endothelin-1 concentrations of the patients in group I were significantly greater than those of the patients in group II (p < 0.05). No significant difference in plasma endothelin-3 concentrations existed between the two groups. Cardiac output and pulmonary capillary wedge pressure had a linear correlation with plasma endothelin-1 levels. There was also a significant correlation between plasma endothelin-1 levels and hemodynamic indicators of severity of pulmonary hypertension, such as mean pulmonary arterial pressure and pulmonary vascular resistance (p < 0.05). All patients in this study underwent surgical procedures for the correction of valvular lesions. All patients in group I showed a decrease in pulmonary arterial pressures, and their plasma endothelin-1 levels decreased from 3.84 +/- 0.20 pg/mL to 1.66 +/- 0.07 pg/mL (p < 0.05), whereas the plasma endothelin-3 levels had only slight variation from 0.64 +/- 0.11 pg/mL to 0.75 +/- 0.06 pg/mL (p > 0.05) between the preoperative and the postoperative stages. The results demonstrated that plasma endothelin-1 rather than endothelin-3 had a role in pulmonary hypertension. Several pieces of evidence pointed out that endothelin-1 functioned as a reactive mediator during vasoconstriction in the case of pulmonary hypertension rather than as a triggering factor of pulmonary hypertension.
Authors:
H Chang; G J Wu; S M Wang; C R Hung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  55     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-08     Completed Date:  1993-03-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  450-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Endothelins / blood*
Female
Heart Valve Diseases / complications,  surgery*
Hemodynamics
Humans
Hypertension, Pulmonary / blood*,  etiology,  physiopathology
Male
Middle Aged
Pulmonary Circulation
Chemical
Reg. No./Substance:
0/Endothelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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