| Plasma endothelin levels during myocardial ischemia and reperfusion. | |
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MedLine Citation:
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PMID: 2020257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin, an endothelium-derived vasoconstrictive peptide, has a strong potency of coronary artery constriction. However, the role of endogeneous endothelin under pathophysiological conditions has not yet been known. In this study, we examined plasma endothelin concentration in dogs with myocardial ischemia and reperfusion. Anesthetized open-chest dogs underwent either 45 minutes occlusion of the left anterior descending coronary artery followed by 3 hours reperfusion, or 4-10 hours of continuous occlusion. Plasma concentration of endothelin from the central vein was measured by the highly sensitive enzyme-immunoassay. Plasma endothelin concentration increased 2.2-fold with the peak level at 60 minutes after release of the ligated artery, but occlusion per se caused no remarkable change. These data suggest that reperfusion of the occluded artery might be needed to increase the plasma concentration of endothelin in case of myocardial infarction. |
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Authors:
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S Tsuji; A Sawamura; H Watanabe; K Takihara; S E Park; J Azuma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 48 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-05-30 Completed Date: 1991-05-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1745-9 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / blood* Coronary Vessels / physiology Dogs Endothelins / blood* Female Male Myocardial Reperfusion* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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