Document Detail

Plasma endothelin in psoriasis: possible relations to therapy and toxicity.
MedLine Citation:
PMID:  8982406     Owner:  NLM     Status:  MEDLINE    
Plasma endothelin levels were studied in 71 patients suffering from severe psoriasis. The psoriatics were treated either with topical therapy alone (n = 18) or with cyclosporin A (n = 26), methotrexate (n = 21), or with hydroxyurea, acitretin or ranitidin (n = 6) with or without topical therapy. The psoriatics had a significantly higher average plasma endothelin than 40 healthy controls. The patients treated with cyclosporin A had the highest values and these were in contrast to patients on methotrexate and other systemic therapy higher than patients treated with topical therapy alone. There was not significant difference between endothelin levels in patients treated with methotrexate compared to those in patients only receiving topical treatment. Whether the increased endothelin levels in plasma are derived from keratinocytes or enlarged vessels need to be investigated. An increased plasma endothelin level could be related to therapy and for patients on cyclosporin A be of importance for toxicity.
H Zachariae; L Heickendorff; P Bjerring
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  76     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  442-3     Citation Subset:  IM    
Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark.
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MeSH Terms
Acitretin / therapeutic use
Cyclosporine / therapeutic use,  toxicity
Endothelins / blood*
Hydroxyurea / therapeutic use
Keratolytic Agents / therapeutic use
Methotrexate / therapeutic use,  toxicity
Psoriasis / blood*,  drug therapy*
Ranitidine / therapeutic use
Reg. No./Substance:
0/Endothelins; 0/Keratolytic Agents; 127-07-1/Hydroxyurea; 55079-83-9/Acitretin; 59-05-2/Methotrexate; 59865-13-3/Cyclosporine; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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