Document Detail

Plasma endothelin in human essential hypertension.
MedLine Citation:
PMID:  2059394     Owner:  NLM     Status:  MEDLINE    
Plasma endothelin immunoreactivity was measured in normal controls, in mild essential hypertensive patients with no antihypertensive treatment, in moderate to severe hypertensives whose blood pressure was controlled by treatment, and in moderate to severe hypertensives whose blood pressure was not controlled by treatment. Endothelin immunoreactivity levels in plasma in the four groups were similar, but had a positive correlation with blood pressure in hypertensives although not in normotensives. The concentration in plasma of both C-terminal and N-terminal atrial natriuretic peptide also had a positive correlation with blood pressure in these hypertensive patients. We conclude that if plasma immunoreactive endothelin levels represent the result of endothelial production of endothelin, in absence of changes in catabolism of the peptide, essential hypertensive patients do not appear to have increased production of endothelin.
E L Schiffrin; G Thibault
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  4     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-02     Completed Date:  1991-08-02     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Clinical Research Institute of Montreál, Québec, Canada.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Endothelins / blood*
Hypertension / blood*,  drug therapy,  physiopathology
Middle Aged
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelins

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