Document Detail

Plasma endothelin-1 release in normal and varicose saphenous veins.
MedLine Citation:
PMID:  9313626     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to investigate the release of endothelin-1 (ET-1) in normal and varicose saphenous veins at baseline and after venous stasis test. Ten patients (eight women and two men, mean age 43 +/- 4) with primarily varicose great saphenous veins and ten controls (eight women and two men, mean age 42 +/- 6) were recruited. After 30 minutes of resting in supine position, venous occlusion in a leg was performed with a sphygmomanometer provided to keep the pressure in the cuff intermediate between systolic and diastolic blood pressure for 10 minutes. Blood samples were taken from the great saphenous vein just above the medial malleolus at baseline and 10 minutes after venous stasis was begun. Plasma ET-1 was determined by a radioimmunoassay system. Results are expressed as mean +/- SD. Plasma ET-1 concentration was higher in varicose than in normal saphenous veins (4 +/- 0.1 pmol/L vs 2.6 +/- 0.1 pmol/L, P < 0.001), and it significantly increased (P < 0.001) in both groups after venous stasis when compared with baseline (6.8 +/- 0.9 pmol/L and 3.6 +/- 0.1 pmol/L in varicose and normal saphenous veins, respectively). Absolute increase in plasma ET-1 was significantly greater in varicose than in normal saphenous veins (2.8 +/- 0.9 pmol/L vs 1.0 +/- 0.2 pmol/L, P < 0.01). In conclusion, increased local ET-1 release in varicose saphenous veins could be a marker for venous endothelial activation/damage and/or contribute to promote the morphologic alterations of the varicose vein wall by stimulating smooth muscle cell proliferation. On the other hand, increased ET-1 release could contribute to counterbalancing the varicose venous relaxation and to increasing preload in varicose patients via ET-1-induced venoconstriction.
R A Mangiafico; L S Malatino; M Santonocito; R S Spada; F A Benedetto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  48     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-31     Completed Date:  1997-10-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-74     Citation Subset:  IM    
Istituto di Clinica Medica L. Condorelli, University of Catania, Italy.
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MeSH Terms
Blood Pressure
Endothelin-1 / blood,  secretion*
Heart Rate
Middle Aged
Muscle, Smooth, Vascular / physiology
Saphenous Vein / metabolism*
Varicose Veins / metabolism*
Reg. No./Substance:

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