Document Detail

Plasma endothelin-1 levels in patients with aldosterone-producing adenoma and pheochromocytoma.
MedLine Citation:
PMID:  8886476     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to evaluate possible changes of plasma endothelin-1 levels (ET-1) in patients with hypertension secondary to primary aldosteronism and pheochromocytoma. We enrolled in the study: 12 patients affected by aldosterone-producing adenoma (5 M and 7 W; mean age 42.1 +/- 17.2 years); 8 patients with pheochromocytoma (5 M, 3 W; mean age 36.2 +/- 17.1 years); 15 patients with essential hypertension (9 M, 6 W; mean age 48.5 +/- 10 years). We also enrolled a normal control group (8 M, 12 W; mean age 34.2 +/- 11 years). The mean plasma ET-1 concentrations in patients with pheochromocytoma were significantly higher (23.9 +/- 5.2 pg/ml) than those in normal subjects (7.3 +/- 1.9 pg/ml), in patients with primary aldosteronism (12.1 +/- 3.8 pg/ml) and in patients with essential hypertension (9.2 +/- 3 pg/ml); p < 0.001, respectively. The present investigation demonstrates that in human adrenal hypertension patients with pheochromocytoma have increased circulating ET-1 levels respect to patients with aldosterone-producing adenoma.
C Letizia; G De Toma; S Cerci; L Scuro; A De Ciocchis; C D'Ambrosio; R Massa; A Cavallaro; D Scavo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  18     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-03     Completed Date:  1997-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-31     Citation Subset:  IM    
I Patologia Medica, University of Rome La Sapienza, Italy.
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MeSH Terms
Adenoma / blood*,  complications
Adrenal Gland Neoplasms / blood*,  complications
Biological Markers
Endothelin-1 / blood*
Hyperaldosteronism / blood*,  etiology
Hypertension / blood*,  etiology
Middle Aged
Pheochromocytoma / blood*,  complications
Reg. No./Substance:
0/Biological Markers; 0/Endothelin-1

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