| Plasma endothelin-1 levels in patients with rheumatic mitral stenosis and a history of cerebral thromboembolism. | |
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MedLine Citation:
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PMID: 15796254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increased plasma endothelin-1 concentrations have been observed in patients with rheumatic mitral stenosis. Endothelin-1 levels have never been investigated in patients with mitral stenosis and history of cerebral thromboembolism. METHODS: We measured plasma concentrations of endothelin-1 in the peripheral venous blood samples obtained from 20 patients with moderate to severe rheumatic mitral stenosis (16 with permanent atrial fibrillation and 4 with sinus rhythm). Six patients had history of thromboembolism. The remaining 14 patients did not have history of thromboembolism. Plasma endothelin-1 concentrations were measured using solid phase sandwich enzyme linked-immuno-sorbent assay. RESULTS: The peripheral venous concentrations of endothelin-1 of the six patients with history of thromboembolism did not differ from the concentrations of the 14 patients without history of thromboembolism (2.40 +/- 1.39 pg/ml vs. 2.49 +/- 0.66 pg/ml, p = 0.9). CONCLUSIONS: Although plasma endothelin-1 concentrations were increased in patients with mitral stenosis, plasma endothelin-1 concentrations were not further elevated in patients with mitral stenosis and history of thromboembolism. |
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Authors:
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Li-Chuan Ma; Mien-Cheng Chen; Hsueh-Wen Chang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chang Gung medical journal Volume: 27 ISSN: 2072-0939 ISO Abbreviation: Chang Gung Med J Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2005-03-30 Completed Date: 2005-04-28 Revised Date: 2008-12-16 |
Medline Journal Info:
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Nlm Unique ID: 101088034 Medline TA: Chang Gung Med J Country: China (Republic: 1949- ) |
Other Details:
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Languages: eng Pagination: 794-800 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrial Fibrillation / etiology Endothelin-1 / blood* Female Humans Intracranial Embolism and Thrombosis / blood* Male Middle Aged Mitral Valve Stenosis / blood* Rheumatic Heart Disease / blood* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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