Document Detail

Plasma endothelin-1 levels in patients with rheumatic mitral stenosis and a history of cerebral thromboembolism.
MedLine Citation:
PMID:  15796254     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased plasma endothelin-1 concentrations have been observed in patients with rheumatic mitral stenosis. Endothelin-1 levels have never been investigated in patients with mitral stenosis and history of cerebral thromboembolism. METHODS: We measured plasma concentrations of endothelin-1 in the peripheral venous blood samples obtained from 20 patients with moderate to severe rheumatic mitral stenosis (16 with permanent atrial fibrillation and 4 with sinus rhythm). Six patients had history of thromboembolism. The remaining 14 patients did not have history of thromboembolism. Plasma endothelin-1 concentrations were measured using solid phase sandwich enzyme linked-immuno-sorbent assay. RESULTS: The peripheral venous concentrations of endothelin-1 of the six patients with history of thromboembolism did not differ from the concentrations of the 14 patients without history of thromboembolism (2.40 +/- 1.39 pg/ml vs. 2.49 +/- 0.66 pg/ml, p = 0.9). CONCLUSIONS: Although plasma endothelin-1 concentrations were increased in patients with mitral stenosis, plasma endothelin-1 concentrations were not further elevated in patients with mitral stenosis and history of thromboembolism.
Li-Chuan Ma; Mien-Cheng Chen; Hsueh-Wen Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chang Gung medical journal     Volume:  27     ISSN:  2072-0939     ISO Abbreviation:  Chang Gung Med J     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-03-30     Completed Date:  2005-04-28     Revised Date:  2008-12-16    
Medline Journal Info:
Nlm Unique ID:  101088034     Medline TA:  Chang Gung Med J     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  794-800     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung.
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MeSH Terms
Atrial Fibrillation / etiology
Endothelin-1 / blood*
Intracranial Embolism and Thrombosis / blood*
Middle Aged
Mitral Valve Stenosis / blood*
Rheumatic Heart Disease / blood*
Reg. No./Substance:

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