Document Detail

Plasma endothelin-1 in patients with stable or unstable angina.
MedLine Citation:
PMID:  14556009     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been documented that an elevated endothelin-1 (ET-1) plasma concentration is associated with an increased risk of serious coronary events and the presence of angiographically documented coronary artery disease (CAD). The results of a few studies which examined ET-1 plasma level in patients with stable or unstable angina, were inconclusive. AIM: To assess whether ET-1 blood concentration measured in the coronary sinus and peripheral vein is associated with clinical symptoms in patients with multi-vessel CAD. METHODS: The study group consisted of 23 patients with multi-vessel CAD of whom 11 had unstable angina and 12 - stable angina. Both groups were matched with regard to age, gender and the presence of cardio-vascular risk factors. Blood samples for ET-1 assessment were taken during coronary angiography simultaneously from the coronary sinus and femoral vein. ET-1 was measured using an immunoenzymatic method. RESULTS: ET-1 plasma level in the peripheral venous circulation was similar in patients with unstable or stable angina (0.45+/-0.18 pmol/L versus 0.46+/-0.14 pmol/L, NS) whereas ET-1 level in the coronary sinus was significantly higher in patients with unstable angina (1.44+/-0.47 pmol/L versus 0.34+/-0.17 pmol/L, p<0.05). CONCLUSIONS: ET-1 concentration in the coronary sinus is significantly higher in patients with unstable rather than stable angina which confirms the role of ET-1 in the pathogenesis of CAD. Our results suggest a possible future role of endothelin receptor blockers in the treatment of patients with unstable angina.
Izabela Zuk-Popiołek; Zbigniew Flak; Tomasz Francuz; Michał Tendera
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Kardiologia polska     Volume:  58     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-10-13     Completed Date:  2004-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  429-37; discussion 436-7     Citation Subset:  IM    
III Department of Cardiology, Silesian Medical Academy, Katowice, Poland.
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MeSH Terms
Angina, Unstable / blood*,  radiography
Coronary Angiography
Endothelin-1 / metabolism*
Middle Aged
Reg. No./Substance:

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