Document Detail


Plasma endothelin-1 concentrations in the coronary sinus in dogs with artificially induced myocardial infarction.
MedLine Citation:
PMID:  1480507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously reported the marked increase in plasma levels of endothelin-1 in patients with acute myocardial infarction (AMI). To investigate the effects of severe myocardial ischemia on the production of endothelin-1, plasma concentrations of endothelin-1 were measured by a sandwich-type enzyme immunoassay that we developed recently in both the coronary sinus and the aorta of dogs with artificially induced AMI. Dogs were anesthetized and chests were opened. The proximal left anterior descending coronary artery was completely occluded by ligation for 1 h and then was reperfused for 1 h. Throughout the experiment (at the end of occlusion for 1 h, at the beginning of reperfusion, at the end of reperfusion for 1 h), plasma endothelin-1 levels were not significantly altered either in the coronary sinus or in the aorta. The present findings indicate that severe myocardial ischemia itself does not affect the production of endothelin-1 in the coronary circulation of dogs.
Authors:
T Miyauchi; T Doi; N Suzuki; M Kakihana; I Yamaguchi; Y Sugishita; T Mitsui; M Hori; T Masaki; K Goto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  13     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1992 Sep-Oct
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1013-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Endothelins / blood*
Myocardial Infarction / blood*,  etiology
Myocardial Ischemia / blood
Myocardial Reperfusion Injury / blood
Chemical
Reg. No./Substance:
0/Endothelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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