Document Detail

Plasma endothelin-1 concentrations in the coronary sinus in dogs with artificially induced myocardial infarction.
MedLine Citation:
PMID:  1480507     Owner:  NLM     Status:  MEDLINE    
We have previously reported the marked increase in plasma levels of endothelin-1 in patients with acute myocardial infarction (AMI). To investigate the effects of severe myocardial ischemia on the production of endothelin-1, plasma concentrations of endothelin-1 were measured by a sandwich-type enzyme immunoassay that we developed recently in both the coronary sinus and the aorta of dogs with artificially induced AMI. Dogs were anesthetized and chests were opened. The proximal left anterior descending coronary artery was completely occluded by ligation for 1 h and then was reperfused for 1 h. Throughout the experiment (at the end of occlusion for 1 h, at the beginning of reperfusion, at the end of reperfusion for 1 h), plasma endothelin-1 levels were not significantly altered either in the coronary sinus or in the aorta. The present findings indicate that severe myocardial ischemia itself does not affect the production of endothelin-1 in the coronary circulation of dogs.
T Miyauchi; T Doi; N Suzuki; M Kakihana; I Yamaguchi; Y Sugishita; T Mitsui; M Hori; T Masaki; K Goto
Related Documents :
21942497 - Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidat...
1990747 - Coronary sinus occlusion: effect on ischemic left ventricular dysfunction and reactive ...
2286427 - Limitation of experimental myocardial infarct size by magnesium sulfate pre-treatment i...
4067107 - Comparative echocardiographic study of recovery of diastolic versus systolic function a...
16645357 - Rationale and design of the gissi-atrial fibrillation trial: a randomized, prospective,...
10627877 - Diagnosis and risk stratification of patients with anginal pain and non-diagnostic elec...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  13     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1992 Sep-Oct
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1013-5     Citation Subset:  IM    
Department of Pharmacology, University of Tsukuba, Ibaraki, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Endothelins / blood*
Myocardial Infarction / blood*,  etiology
Myocardial Ischemia / blood
Myocardial Reperfusion Injury / blood
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Protective effect of cerulein on memory impairment induced by protein synthesis inhibitors in rats.
Next Document:  C-type natriuretic peptide immunoreactivity in human breast vascular endothelial cells.