| Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations. | |
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MedLine Citation:
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PMID: 20576209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Met- and leu-enkephalins are endogenous opioid neuropeptides with potent analgesic, vasoactive, immunomodulatory and anti-apoptotic properties. We hypothesised that clinical or immunological variables of early systemic sclerosis (SSc) might be correlated to plasma enkephalin levels. METHODS: Plasma samples were collected at study entry of the Genetics versus Environment in Scleroderma Outcomes Study (GENISOS) cohort (early SSc, n=116). Plasma met-enkephalin and leu-enkephalin levels (microg/ml) were measured by high performance liquid chromatography (HPLC) and correlated to clinical and laboratory parameters in the GENISOS database. Statistical analyses were performed by nonparametric Wilcoxon rank sum tests and Pearson correlation coefficients. RESULTS: Significantly lower plasma met-enkephalin levels were associated with anti-topoisomerase-I seropositivity (6+8.3 vs. 14.9+22.8 microg/ml, p=0.02). Plasma leu-enkephalin levels were significantly higher in SSc patients with digital pulp loss (95.6+130 vs. 64.9+101 microg/ml, p=0.02). Lower mean plasma met-enkephalin levels and inversely higher leu-enkephalin levels were noted in SSc patients with Raynaud's phenomena (p=NS). CONCLUSION: The associations of plasma enkephalin levels to immunologic or clinical pathologies may underscore their vasogenic or fibrogenic significance and potential as therapeutic targets in early SSc. |
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Authors:
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Terry A McNearney; K A Sluka; C Ahn; J D Reveille; Michael Fischbach; Maureen D Mayes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-10 |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 28 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-16 Revised Date: 2011-10-12 |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: S7-11 Citation Subset: IM |
Affiliation:
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Division of Rheumatology-UTMB, 301 University Blvd., Galveston, TX 77555-1165, USA. tmcnearn@utmb.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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immunology Chromatography, High Pressure Liquid DNA Topoisomerases, Type I / immunology Enkephalin, Leucine / blood*, physiology Enkephalin, Methionine / blood*, physiology Female Humans Male Middle Aged Neurotransmitter Agents / blood*, physiology Scleroderma, Diffuse / blood*, immunology, physiopathology Scleroderma, Limited / blood*, immunology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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AR052316/AR/NIAMS NIH HHS; K0202201//PHS HHS; M01-RR00073/RR/NCRR NIH HHS; M01-RR01346/RR/NCRR NIH HHS; M01-RR02558/RR/NCRR NIH HHS; NS39734/NS/NINDS NIH HHS; P50 AR044888-06/AR/NIAMS NIH HHS; P50 AR054144-03/AR/NIAMS NIH HHS; P50AR054144/AR/NIAMS NIH HHS; P50AR44888/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Neurotransmitter Agents; 58569-55-4/Enkephalin, Methionine; 58822-25-6/Enkephalin, Leucine; EC 5.99.1.2/DNA Topoisomerases, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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