Document Detail


Plasma dopamine-beta-hydroxylase activity and blood pressure variability in hypertensive man.
MedLine Citation:
PMID:  487618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been proposed that measurements of plasma dopamine-beta-hydroxylase (DBH) may allow for assessmetn of adrenergic tone and may elucidate a possible neurogenic contribution to essential hypertension. We performed a series of measurements of DBH in fifty-seven normotensive and fifty hypertensive black and white men in order (1) to compare DBH to selected blood pressure patterns and (2) to evalutate the influence of salt intake, posture and race on plasma DBH. Plasma DBH, measured on unrestricted salt intake with subjects supine, was 42 +/- 4 Units/L in white normotensives, greater (P less than 0.05) than black normotensives (26 +/- 6 Units/L). White hypertensives had greater plasma concentrations of DBH than black (35 +/- 3 VS. 24 +/- 5, P less than 0.05). Normotensives did not differ from hypertensives. Dietary salt restriction and upright ambulation increased plasma DBH activity in hypertensives. Although DBH did not correlate directly with blood pressure, high DBH values were associated with lability of blood pressure in hypertensives but not in normotensives. There are two possible explanations for our results: (1) multiple factors influence plasma DBH activity and plasma levels reflect more than adrenergic function, or (2) essential hypertension is a multifactorial disease and excess sympathetic neuronal activity alone is not sufficient to produce sustained hypertension.
Authors:
S B Levy; R F Frigon; R A Stone
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical endocrinology     Volume:  11     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1979  
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  187-99     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Blood Pressure*
Diet
Dopamine beta-Hydroxylase / blood*
European Continental Ancestry Group
Humans
Hypertension / blood,  enzymology*,  physiopathology
Male
Middle Aged
Posture
Sodium Chloride / metabolism
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride; EC 1.14.17.1/Dopamine beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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