Document Detail

Plasma dimethylarginine levels in chronic hemodialysis patients are independent of the type of dialyzer applied.
MedLine Citation:
PMID:  17622710     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Asymmetric dimethylarginine (ADMA) levels are increased in hemodialysis (HD) patients. Reports on the effect of various dialysis strategies on ADMA, symmetric dimethylarginine (SDMA) and L-arginine levels are inconclusive.
PATIENTS/METHODS: In this randomized crossover study, 15 patients were dialyzed for 4 weeks with 4 dialyzers, differing in biocompatibility and flux. Dimethylarginine and L-arginine levels were assessed at baseline, and after 4 weeks both before and after HD.
RESULTS: During HD, ADMA and SDMA levels decreased significantly with all dialyzers. Dimethylarginine and L-arginine levels remained stable after 4 weeks of HD with each membrane. After pooling all data, values were mainly explained by variation between time points and patients, not by the type of dialyzer.
CONCLUSION: Despite an intradialytic decrease in dimethylarginines, no changes occurred after 4 weeks of HD with either membrane. Furthermore, the variability of AMDA, SDMA and L-arginine levels was far more dependent on patient-related factors than on the type of dialyzer applied.
Muriel P C Grooteman; Inge M P M J Wauters; Tom Teerlink; Jos W R Twisk; Menso J Nubé
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-07-02
Journal Detail:
Title:  Blood purification     Volume:  25     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-10-26     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  281-9     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Arginine / analogs & derivatives*,  blood
Biocompatible Materials
Complement C3a / analysis
Cross-Over Studies
Equipment Design
Kidney Failure, Chronic / blood*,  therapy
Membranes, Artificial
Middle Aged
Nitric Oxide / metabolism
Prospective Studies
Renal Dialysis / instrumentation*
beta 2-Microglobulin / analysis
Reg. No./Substance:
0/Biocompatible Materials; 0/Membranes, Artificial; 0/beta 2-Microglobulin; 0/complement C3a, des-Arg-(77)-; 10102-43-9/Nitric Oxide; 30315-93-6/N,N-dimethylarginine; 30344-00-4/N,N'-dimethylarginine; 74-79-3/Arginine; 80295-42-7/Complement C3a

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