Document Detail


Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy.
MedLine Citation:
PMID:  22431533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the market for venous thromboembolic prophylaxis and for stroke prevention in atrial fibrillation. While dabigatran has been approved for use without the need for routine therapeutic monitoring, there are clinical scenarios in which monitoring can help guide clinical management. We report herein the application of a recently described plasma-diluted thrombin time (DTI assay) used to monitor intravenous DTI as a useful and easily implemented method to monitor oral DTIs.
Authors:
Scott T Avecilla; Chris Ferrell; Wayne L Chandler; Morayma Reyes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  137     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-20     Completed Date:  2012-05-04     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-4     Citation Subset:  AIM; IM    
Affiliation:
Laboratory Medicine, University of Washington, Seattle, USA.
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MeSH Terms
Descriptor/Qualifier:
Antithrombin Proteins / administration & dosage,  therapeutic use*
Atrial Fibrillation / drug therapy*
Benzimidazoles / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Humans
Pyridines / administration & dosage,  therapeutic use*
Stroke / prevention & control*
Thrombin Time
Chemical
Reg. No./Substance:
0/Antithrombin Proteins; 0/Benzimidazoles; 0/Pyridines; 2E18WX195X/dabigatran etexilate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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