Document Detail


Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study.
MedLine Citation:
PMID:  14973107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between plasma carotenoids and prostate cancer risk was investigated in a case-control study nested within the prospective Health Professionals Follow-up Study. We matched 450 incident prostate cancer cases diagnosed from 1993-1998 to 450 controls by age, time, month, and year of blood donation. Modest inverse, but not statistically significant, associations were observed among plasma alpha-carotene, beta-carotene, and lycopene concentrations, and overall risk of prostate cancer diagnosis [odds ratio (highest versus lowest quintile; OR), alpha-carotene: OR, 0.67 [95% confidence interval (CI), -0.40-1.09]; beta-carotene: OR, 0.78 (95% CI, 0.48-1.25); lycopene: OR, 0.66 (95% CI, 0.38-1.13)]. The inverse association between plasma lycopene concentrations and prostate cancer risk was limited to participants who were 65 years or older (OR, 0.47; 95% CI, 0.23-0.98) and without a family history of prostate cancer (OR, 0.48; 95% CI, 0.26-0.89). Combining, older age and a negative family history provided similar results (OR, 0.43; 95% CI, 0.18-1.02). Inverse associations between beta-carotene and prostate cancer risk were also found among younger participants (<65 years of age; OR, 0.36; 95% CI, 0.14-0.91; P(trend) = 0.03). Combining dietary intake and plasma data confirmed our results. We found a statistically significant inverse association between higher plasma lycopene concentrations and lower risk of prostate cancer, which was restricted to older participants and those without a family history of prostate cancer. This observation suggests that tomato products may exhibit more potent protection against sporadic prostate cancer rather than those with a stronger familial or hereditary component. In addition, our findings also suggest that among younger men, diets rich in beta-carotene may also play a protective role in prostate carcinogenesis.
Authors:
Kana Wu; John W Erdman; Steven J Schwartz; Elizabeth A Platz; Michael Leitzmann; Steven K Clinton; Valerie DeGroff; Walter C Willett; Edward Giovannucci
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  13     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-9     Citation Subset:  IM    
Affiliation:
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kana.wu@channing.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Carotenoids / blood*,  pharmacology*
Case-Control Studies
Diet*
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Pedigree
Prostatic Neoplasms / genetics,  prevention & control*
Risk Assessment
Grant Support
ID/Acronym/Agency:
CA 55075/CA/NCI NIH HHS; CA 72036/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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