Document Detail

Plasma cyclic AMP and cyclic GMP in childhood-onset psychoses.
MedLine Citation:
PMID:  6086565     Owner:  NLM     Status:  MEDLINE    
Plasma cyclic AMP is a "second messenger" that may reflect levels of activity of important neurotransmitter receptors. Plasma cyclic AMP was measured in 18 patients with childhood autism, 7 patients with pervasive developmental disorder, and 12 age- and sex-matched healthy controls. Plasma cyclic AMP was significantly elevated by over 100% in both groups of patients with childhood-onset psychoses compared with controls. Plasma cyclic GMP, a nucleotide linked to different receptors, was not elevated, suggesting that the finding may be specific.
M Goldberg; J Hattab; D Meir; R P Ebstein; R H Belmaker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  14     ISSN:  0162-3257     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-06     Completed Date:  1984-09-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
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MeSH Terms
Autistic Disorder / blood
Cyclic AMP / blood*
Cyclic GMP / blood*
Delirium, Dementia, Amnestic, Cognitive Disorders / blood
Psychotic Disorders / blood*
Schizophrenia, Childhood / blood
Reg. No./Substance:
60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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