Document Detail

Plasma corticotropin-releasing hormone, corticotropin, and endorphins at rest and during exercise in eumenorrheic and amenorrheic athletes.
MedLine Citation:
PMID:  2840309     Owner:  NLM     Status:  MEDLINE    
The hypothalamic-pituitary response to exercise was studied in 12 amenorrheic and in 9 eumenorrheic athletes by comparing the concentrations of corticotropin-releasing hormone (CRH), corticotropin (ACTH), and endorphins (beta-endorphin + beta-lipotropin) in plasma at rest and during an acute exercise on a bicycle ergometer requiring 80% and 100% of the maximal oxygen uptake (VO2 max). Plasma CRH levels did not change during the exercise, and the mean CRH values did not differ between the amenorrheic and eumenorrheic groups. In both groups, significant increases in the response to exercise were found in the concentrations of ACTH and endorphins. The only significant difference between the groups was a larger mean pre-exercise concentration of endorphins in amenorrheic than in eumenorrheic athletes (4.8 +/- 0.8 standard error [SE] and 2.9 +/- 0.2 pmol/l, respectively). It is concluded that in amenorrheic athletes the capacity of the anterior pituitary to secrete ACTH and endorphins in response to exercise does not significantly differ from that in eumenorrheic athletes, although basal endorphin secretion may be increased.
H Hohtari; R Elovainio; K Salminen; T Laatikainen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  50     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
The Finnish Foundation of Exercise and Sports Medicine, Helsinki, Finland.
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MeSH Terms
Adrenocorticotropic Hormone / blood*
Amenorrhea / blood*,  etiology
Corticotropin-Releasing Hormone / blood*
Endorphins / blood*
Physical Exertion*
beta-Endorphin / blood
beta-Lipotropin / blood
Reg. No./Substance:
0/Endorphins; 60617-12-1/beta-Endorphin; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone; 9035-55-6/beta-Lipotropin

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