Document Detail

Plasma copper concentration as marker of copper intake from food.
MedLine Citation:
PMID:  11053900     Owner:  NLM     Status:  MEDLINE    
Copper concentration in blood plasma is used mainly as an indicator for alimentary copper supply. This has some limitations because copper concentration in plasma fluctuates with age, exercise and health status and does not increase after a meal nor decrease during short-term fasting. The Austrian Study on Nutritional Status (ASNS) provides data on nutrient intake and corresponding plasma concentrations, permitting to evaluate the suitability of copper plasma concentration as a marker of copper intake. Copper intake and intake of relevant nutrients and food groups were evaluated from 7-day weighed food records from 2,400 preschool and schoolchildren between 4 and 19 years of age. Blood samples were collected from a subgroup of 1,400 of these children. The copper concentration in plasma was measured by graphite furnace atomic absorption spectrometry. Correlations between plasma concentrations and intake of nutrients and food groups were calculated using a stepwise linear regression model. The results showed that the determination of copper plasma concentrations are inadequate to predict copper intake from dietary records. A better indicator for copper supply may be the evaluation of those food items, which are the predominant sources of copper intake at the population level. The highest influence on copper plasma concentration was found for the intake of meat, representing not only the most important food group for copper supply but also the most important food group for fat and protein supply. The individual copper status can only be estimated accurately when information on characteristic enzyme activities under control of additional factors of influence or even body stores of copper are available.
J S König; I Elmadfa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  44     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Institute of Nutritional Sciences, University of Vienna, Austria.
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MeSH Terms
Biological Markers
Child, Preschool
Copper / administration & dosage*,  blood
Diet Records*
Linear Models
Mass Spectrometry
Nutrition Assessment
Reg. No./Substance:
0/Biological Markers; 7440-50-8/Copper

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