| Plasma concentrations of vitamin K1 and PIVKA-II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth. | |
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MedLine Citation:
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PMID: 3234435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma vitamin K1 and proteins induced by vitamin K absence (PIVKA) were assayed simultaneously 1-4 days and 29-35 days after delivery in three groups of infants: breast-fed not receiving vitamin K at birth (n = 12), bottle-fed without vitamin K administration at birth (n = 7) and breast-fed receiving 1 mg vitamin K1 administered by intramuscular injection at birth (n = 13). The bottle-fed infants had a significantly higher vitamin K1 plasma level than breast-fed infants who did not receive vitamin K1 at birth. Extremely high levels of vitamin K were obtained 1-4 days after intramuscular administration. At the age of 1 month, breast-fed infants had the same plasma vitamin K1 concentration whether or not they had received vitamin K1 supplements. Decarboxy prothrombin (PIVKA-II) a reliable indicator of biochemical vitamin K deficiency, was found in 5 out of 12 breast-fed and in 2 out of 6 bottle-fed infants who had not received supplemental vitamin K1 after birth. In a separate study, we followed up to 90 days after birth a larger group if infants. PIVKA-II was found with significantly greater frequency in breast-fed infants receiving no vitamin K than in breast-fed infants receiving 1 mg vitamin K intramuscularly at birth, or in bottle-fed infants without extra vitamin K1. These data form a strong argument for routine vitamin K prophylaxis after birth for all breast-fed infants. The optimum dose and manner of administration require further study. |
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Authors:
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J Widdershoven; W Lambert; K Motohara; L Monnens; A de Leenheer; I Matsuda; F Endo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pediatrics Volume: 148 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1989-05-01 Completed Date: 1989-05-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 139-42 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Catholic University of Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers* Bottle Feeding / methods* Breast Feeding* Half-Life Humans Infant Infant, Newborn Protein Precursors / blood*, metabolism Prothrombin / blood*, metabolism Umbilical Cord / analysis Vitamin K / administration & dosage Vitamin K 1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protein Precursors; 12001-79-5/Vitamin K; 53230-14-1/acarboxyprothrombin; 84-80-0/Vitamin K 1; 9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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