Document Detail

Plasma concentrations of tumor necrosis factor alpha may predict the outcome of patients with acute renal failure.
MedLine Citation:
PMID:  16960458     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Elevated plasma tumor necrosis factor-alpha (TNFalpha) concentration is frequently found in patients with chronic renal failure on hemodialysis (HD) and correlates with their mortality. The present study aimed to analyze the relationship between plasma TNFalpha concentrations and survival of patients with nonseptic acute renal failure (ARF). METHODS: Twenty-seven patients with ARF and 27 HD patients were examined. In ARF the patients' plasma TNFalpha concentrations were assessed 3 times: before the first HD session (phase I), 5 days later at the anuric/oliguric phase (phase II), and at the polyuric phase at discharge of the patients from the hospital (phase III). In 17 ARF patients kidney function recovered and 10 patients died in phase I. RESULTS: In ARF patients plasma TNFalpha concentration was markedly higher [70 pg/ml (37-275)] than reference values (<5 pg/ml) but significantly lower than in HD patients [216 pg/ml (18-350)]. Moreover, also plasma TNFalpha levels at the polyuric phase remained elevated. An initial plasma TNFalpha concentration in ARF patients lower than 70 pg/ml predicted the beneficial outcome with a sensitivity of 64.7% and a specificity of 70.0%. CONCLUSIONS: (1) Plasma TNFalpha concentration may predict the outcome in patients with ARF. (2) Plasma TNFalpha concentration remained elevated at the polyuric phase in ARF despite a marked improvement of excretory kidney function.
Rafał Ficek; Franciszek Kokot; Jerzy Chudek; Marcin Adamczak; Joanna Ficek; Andrzej Wiecek
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Publication Detail:
Type:  Journal Article     Date:  2006-09-08
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  29     ISSN:  1420-4096     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
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MeSH Terms
Biological Markers / blood
Kidney / physiology
Kidney Failure, Acute / blood*,  mortality,  therapy*
Kidney Failure, Chronic / blood,  mortality,  therapy
Middle Aged
Predictive Value of Tests
ROC Curve
Renal Dialysis*
Survival Rate
Treatment Outcome
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/Biological Markers; 0/Tumor Necrosis Factor-alpha

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