Document Detail

Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
MedLine Citation:
PMID:  1155069     Owner:  NLM     Status:  MEDLINE    
The plasma concentration of phenobarbital given as anticonvulsive treatment in the newborn period has been followed in 18 infants. With constant daily doses, the drug accummulated for at least 5 days. After intramuscular injection of a single dose, 90% of the peak concentration was reached within 4 hours in 8 of the 10 infants. The peak concentration (in mug/ml) approximately equalled 1.3 x the dose (in mg/kg). Absorption after oral administration was less reliable. In 12 of the infants the clinical course allowed attempts to evaluate the anticonvulsive effect of phenobarbital. In 4 cases the convulsions continued. In those 8 infants where phenobarbital seemed to be effective, the approximate range of phenobarbital concentration when convulsions ceased was 12-30 mug/ml. Phenobarbital half-life ranged between 59 and 182 hours. In some infants the rate of phenobarbital disappearance from the plasma varied considerably from day to day. The pathological conditions causing seizures probably influence the distribution, metabolism and excretion of the drug. For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration.
B Jalling
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  64     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  514-24     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Diazepam / therapeutic use
Dose-Response Relationship, Drug
Infant, Newborn
Infant, Premature
Injections, Intramuscular
Lidocaine / therapeutic use
Phenobarbital / administration & dosage,  blood*,  therapeutic use
Seizures / blood*,  drug therapy
Reg. No./Substance:
0/Tablets; 137-58-6/Lidocaine; 439-14-5/Diazepam; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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