Document Detail


Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
MedLine Citation:
PMID:  1155069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The plasma concentration of phenobarbital given as anticonvulsive treatment in the newborn period has been followed in 18 infants. With constant daily doses, the drug accummulated for at least 5 days. After intramuscular injection of a single dose, 90% of the peak concentration was reached within 4 hours in 8 of the 10 infants. The peak concentration (in mug/ml) approximately equalled 1.3 x the dose (in mg/kg). Absorption after oral administration was less reliable. In 12 of the infants the clinical course allowed attempts to evaluate the anticonvulsive effect of phenobarbital. In 4 cases the convulsions continued. In those 8 infants where phenobarbital seemed to be effective, the approximate range of phenobarbital concentration when convulsions ceased was 12-30 mug/ml. Phenobarbital half-life ranged between 59 and 182 hours. In some infants the rate of phenobarbital disappearance from the plasma varied considerably from day to day. The pathological conditions causing seizures probably influence the distribution, metabolism and excretion of the drug. For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration.
Authors:
B Jalling
Related Documents :
24655649 - The broader autism phenotype in infancy: when does it emerge?
23211119 - Assessment of oxidant/anti-oxidant system in newborns and their breast milks.
8393359 - Decreased growth rate of low-birth-weight infants with prolonged maximum renal acid sti...
3761089 - Increased urinary excretion of inorganic sulfate in premature infants fed bovine milk p...
6969879 - Neonatal neutrophilia: possible role of a humoral granulopoietic factor.
23930249 - Early versus delayed initiation of nasal continuous positive airway pressure for treatm...
2925579 - Specificity of infants' response to mothers' affective behavior.
9917489 - Congenital hypothyroidism and nonimmune hydrops fetalis: associated?
23010599 - The influence of the tübingen soft palate plate and early cleft closure on the nasopha...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  64     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  514-24     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Diazepam / therapeutic use
Dose-Response Relationship, Drug
Female
Humans
Infant, Newborn
Infant, Premature
Injections, Intramuscular
Lidocaine / therapeutic use
Male
Phenobarbital / administration & dosage,  blood*,  therapeutic use
Seizures / blood*,  drug therapy
Tablets
Chemical
Reg. No./Substance:
0/Tablets; 137-58-6/Lidocaine; 439-14-5/Diazepam; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Post-mortem distribution and tissue concentrations of digoxin in infants and adults.
Next Document:  Gastric emptying in newborns and young infants. Measurement of the rate of emptying using indium-113...