Document Detail


Plasma concentrations of myeloperoxidase in endurance and 3-day event horses after a competition.
MedLine Citation:
PMID:  17402436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
REASON FOR PERFORMING STUDY: In man, exercise of any type has been shown to induce neutrophil degranulation and respiratory burst activity, as well as an increase in plasma myeloperoxidase (MPO), a specific enzyme of neutrophil azurophilic granules with a strong oxidative activity. Until now, it is not known whether this is the same in horses. OBJECTIVES: To study whether degranulation of blood neutrophils may be induced by exercise by measuring the total concentration of MPO and assess the possible influence of type of competition on this exercise-induced adjustment. METHODS: Blood was sampled before, and 30 min after, the course, in 9 ponies performing the Phase D of a national 3-day event championship (CIC*), and in 7 endurance horses participating at the European endurance championship 2005. White blood cells and granulocytes, total plasma proteins, creatine phosphokinase (CK), and total MPO contents were determined from blood samples. In addition, blood was taken from all ponies and 4 of the endurance horses 5 min after completion of the course to give some idea of the intensity of exercise. RESULTS: The mean blood lactate was 15.8 +/- 5.8 mmol/l after the CIC* and 2.7 +/- 0.2 mmol/l after the 160 km course. Performing both competitions induced a significant increase in CK and MPO. After the endurance course, the number of granulocytes significantly increased. Whilst there was no significant correlation between the measurements in CIC* ponies, MPO was significantly correlated with granulocyte count (r2 = 0.776) and CK (r2 = 0.586) in endurance horses. CONCLUSIONS: Intense exercise induces an activation of blood granulocytes, with degranulation of neutrophils and release of MPO. The plasmatic MPO concentration after endurance was higher than the values reported in some inflammatory pathological conditions. POTENTIAL RELEVANCE: This phenomenon may partly contribute to the occurrence of an exercise-induced oxidative stress and to the alteration of muscular membrane permeability. Further studies should be conducted to assess the possible relationship between MPO concentration and markers of oxidative stress in performance horses.
Authors:
T Art; T Franck; M Gangl; D Votion; S Kohnen; G Deby-Dupont; D Serteyn
Related Documents :
1846116 - The effect of acute exercise on the secretion of corticotropin-releasing factor, argini...
17402436 - Plasma concentrations of myeloperoxidase in endurance and 3-day event horses after a co...
9582966 - Effect of high-intensity exercise on arterial blood gas tensions and upper airway and c...
8578906 - Effect of exercise on enzymatic activity in tracheal fluid and on intrapleural pressure...
15659126 - Objective measures of health-related quality of life over 24 months post-liver transpla...
7435586 - Improvement by isosorbide dinitrate of exercise-induced regional myocardial dysfunction.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2007-04-03     Completed Date:  2007-05-02     Revised Date:  2007-05-18    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Affiliation:
Equine Sports Medicine Centre, University of Liege, Bat B42, Sart-Tilman, B4000 Liege, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Blood Proteins / analysis
Creatine Kinase / blood
Horses* / blood,  physiology
Leukocyte Count / veterinary
Muscle, Skeletal / metabolism
Neutrophils / enzymology*
Oxidative Stress
Peroxidase / blood*
Physical Conditioning, Animal / physiology*
Physical Endurance / physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; EC 1.11.1.7/Peroxidase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in arterial, mixed venous and intraerythrocytic concentrations of ions in supramaximally exe...
Next Document:  Effects of a pre-moistened multilayered breathable fabric in promoting heat loss during recovery aft...