Document Detail


Plasma concentrations of lysolecithin and other phospholipids in the healthy population and in men suffering from atherosclerotic diseases.
MedLine Citation:
PMID:  1156468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentrations of individual phospholipids and of cholesterol have been determined in plasma samples taken from 77 apparently healthy individuals, and from 76 male patients presenting with atherosclerotic diseases. Significant differences in the relative and absolute concentrations of lysolecithin were found between different populations. In healthy individuals the plasma levels of lysolecithin were lower in women than in men and lower in the younger age groups studied. The relative and absolute concentrations of plasma lysolecithin were lower in men suffering from chronic ischaemic heart disease and peripheral arterial disease when compared with age-matched healthy male subjects. The lowest levels of plasma lysolecthin were, however, associated with patients suffering from acute myocardial infarction or acute myocardial ischaemia studied within 48 hr of the onset of chest pain. In a further study, significantly decreased relative concentrations of lysolecithin were found in blood platelets and erythrocytes as well as in plasma of patients suffering from chronic ischaemic heart disease. The results are discussed in terms of a possible thrombo-protective role for plasma lysolecithin in man.
Authors:
M P Gillett; E M Besterman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  22     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:    1975 Jul-Aug
Date Detail:
Created Date:  1975-11-01     Completed Date:  1975-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Age Factors
Aged
Arteriosclerosis / blood*
Blood Platelets / analysis
Cholesterol / blood
Chronic Disease
Coronary Disease / blood
Erythrocytes / analysis
Female
Humans
Lysophosphatidylcholines / blood
Male
Middle Aged
Phospholipids / analysis,  blood*
Sex Factors
Chemical
Reg. No./Substance:
0/Lysophosphatidylcholines; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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