| Plasma concentrations and coronary vasodilation after sublingual and intracoronary administration of isosorbide dinitrate. | |
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MedLine Citation:
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PMID: 8590533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the relationship between plasma levels and coronary vasodilation after administration of isosorbide dinitrate (ISDN), the plasma concentration and diameters of six segments of the left coronary artery were measured before and after sublingual (SL) ISDN (5 mg) and left intracoronary (IC) administration of ISDN (3 mg) in 12 patients. After SL-ISDN, the systolic aortic pressure decreased with no significant concomitant changes in heart rate or diastolic aortic pressure. After IC-ISDN, all hemodynamic parameters showed significant changes, and these were greater after IC-ISDN than those after SL-ISDN. The individual mean vasodilation of six segments induced by SL- and IC-ISDN, were 23 +/- 9 and 35 +/- 11% (p < 0.01), respectively. Before SL-ISDN, ISDN was not detected in plasma. After SL- and IC-ISDN, however, the plasma values of the ISDN were 36.1 +/- 53.3 and 101.5 +/- 90.0 ng/ml (p < 0.01), respectively. Thus, both coronary vasodilative responses and plasma ISDN levels after IC-ISDN were significantly greater than those after SL-ISDN. However, neither the individual mean coronary vasodilation nor the hemodynamic changes correlated significantly with plasma ISDN levels. Consequently, with administration of the same dose, the coronary vasodilative response to ISDN did not correlate with plasma levels. Furthermore, IC-ISDN dilutes coronary arteries more effectively than SL-ISDN. |
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Authors:
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A Hoshio; K Shirota; N Sasaki; T Doi; Y Sawada; M Fukuki; H Miyakoda; H Kotake; H Mashiba |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 18 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-03-28 Completed Date: 1996-03-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 641-6 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Sublingual Aged Coronary Angiography Coronary Vessels / drug effects*, physiology* Female Hemodynamics / drug effects Humans Infusions, Intravenous Isosorbide Dinitrate / blood*, pharmacology* Male Middle Aged Vasodilator Agents / blood*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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