Document Detail

Plasma concentration of malaria parasite-derived macrophage migration inhibitory factor in uncomplicated malaria patients correlates with parasitemia and disease severity.
MedLine Citation:
PMID:  20702656     Owner:  NLM     Status:  MEDLINE    
Host macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infections. Several Plasmodium parasite-derived MIFs were identified to have the potential to regulate host immune response. However, the role of Plasmodium MIFs in the immunopathogenesis of malaria infection and the relationships between these mediators and inflammatory cytokines remained unclear. In this study, we have investigated two Plasmodium MIFs in peripheral blood of uncomplicated malaria patients and analyzed their correlations with several major factors during malaria infection. We found that both Plasmodium falciparum MIF (PfMIF) and Plasmodium vivax MIF (PvMIF) levels in patients were positively correlated with parasitemia, tumor necrosis factor alpha, interleukin-10 (IL-10), and monocyte chemoattractant protein 1 but were not correlated with transforming growth factor β1 and IL-12. Of interest was that the PvMIF level was positively correlated with host body temperature and human MIF (HuMIF) concentrations. Moreover, multiple stepwise regression analysis also showed that parasitemia, IL-10, and HuMIF expression were significant predictors of Plasmodium MIF production. In addition, during antimalarial drug treatment, the decreasing of Plasmodium MIF concentrations was followed by parasitemia in most patients. Our results suggested that the Plasmodium MIF circulating level reflects the level of parasitemia and thus was closely correlated with disease severity in uncomplicated malaria. Therefore, this factor has the potential to be a promising disease predictor and is applicable in clinical diagnosis.
Cong Han; Yahui Lin; Guangliang Shan; Zaixing Zhang; Xiaodong Sun; Zhensheng Wang; Chunyan Wei; Yan Deng; Lianhui Zhang; Lingyi Bu; Dingding Shao; Heng Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-11
Journal Detail:
Title:  Clinical and vaccine immunology : CVI     Volume:  17     ISSN:  1556-679X     ISO Abbreviation:  Clin. Vaccine Immunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101252125     Medline TA:  Clin Vaccine Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1524-32     Citation Subset:  IM    
Department of Microbiology and Parasitology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, China.
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MeSH Terms
Biological Markers
Child, Preschool
Interleukin-10 / biosynthesis
Interleukin-12 / blood
Macrophage Migration-Inhibitory Factors / blood*,  immunology
Malaria, Falciparum / diagnosis,  immunology*,  parasitology,  pathology*
Malaria, Vivax / diagnosis,  immunology*,  parasitology,  pathology*
Middle Aged
Molecular Sequence Data
Plasmodium falciparum / immunology,  pathogenicity
Plasmodium vivax / immunology,  pathogenicity
Protozoan Proteins / blood*,  immunology
Sequence Analysis, DNA
Severity of Illness Index
Transforming Growth Factor beta1 / blood
Tumor Necrosis Factor-alpha / blood
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Macrophage Migration-Inhibitory Factors; 0/Protozoan Proteins; 0/Transforming Growth Factor beta1; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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